%0 Journal Article
%A Grothe, Michel J
%A Moscoso, Alexis
%A Silva-Rodriguez, Jesus
%A Lange, Catharina
%A Nho, Kwangsik
%A Saykin, Andrew J
%A Nelson, Peter T
%A Schöll, Michael
%A Buchert, Ralph
%A Teipel, Stefan
%T Differential diagnosis of amnestic dementia patients based on an FDG-PET signature of autopsy-confirmed LATE-NC.
%D 2022
%U http://hdl.handle.net/10668/20285
%X Limbic age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) is common in advanced age and can underlie a clinical presentation mimicking Alzheimer's disease (AD). We studied whether an autopsy-derived fluorodeoxyglucose positron emission tomography (FDG-PET) signature of LATE-NC provides clinical utility for differential diagnosis of amnestic dementia patients. Ante mortem FDG-PET patterns from autopsy-confirmed LATE-NC (N = 7) and AD (N = 23) patients were used to stratify an independent cohort of clinically diagnosed AD dementia patients (N = 242) based on individual FDG-PET profiles. Autopsy-confirmed LATE-NC and AD groups showed markedly distinct temporo-limbic and temporo-parietal FDG-PET patterns, respectively. Clinically diagnosed AD dementia patients showing a LATE-NC-like FDG-PET pattern (N = 25, 10%) were significantly older, showed less abnormal AD biomarker levels, lower APOE ε4, and higher TMEM106B risk allele load. Clinically, they exhibited a more memory-predominant profile and a generally slower disease course. An autopsy-derived temporo-limbic FDG-PET signature identifies older amnestic patients whose clinical, genetic, and molecular biomarker features are consistent with underlying LATE-NC.
%K TDP-43
%K TMEM106B
%K amyloid
%K apolipoprotein E
%K autopsy
%K fluorodeoxyglucose positron emission tomography
%K hippocampal sclerosis
%K limbic age-related TDP-43 encephalopathy
%K tau
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