RT Journal Article
T1 Mycophenolate Improves Brain-Gut Axis Inducing Remodeling of Gut Microbiota in DOCA-Salt Hypertensive Rats
A1 Robles-Vera, Iñaki
A1 de la Visitación, Néstor
A1 Sánchez, Manuel
A1 Gómez-Guzmán, Manuel
A1 Jiménez, Rosario
A1 Moleón, Javier
A1 González-Correa, Cristina
A1 Romero, Miguel
A1 Yang, Tao
A1 Raizada, Mohan K.
A1 Toral, Marta
A1 Duarte, Juan
K1 Mycophenolate
K1 Gut dysbiosis
K1 Hypertension
K1 Oxidative stress
K1 Inflammation
K1 (Deoxycorticosterone acetate) DOCA-salt model
K1 Hipertensión
K1 Microbiota
K1 Estrés oxidativo
K1 Inflamación
K1 Acetato de desoxicorticosterona
AB Microbiota is involved in the host blood pressure (BP) regulation. The immunosuppressive drug mofetil mycophenolate (MMF) ameliorates hypertension. The present study analyzed whether MMF improves dysbiosis in mineralocorticoid-induced hypertension. Male Wistar rats were assigned to three groups: untreated (CTR), deoxycorticosterone acetate (DOCA)-salt, and DOCA treated with MMF for 4 weeks. MMF treatment reduced systolic BP, improved endothelial dysfunction, and reduced oxidative stress and inflammation in aorta. A clear separation in the gut bacterial community between CTR and DOCA groups was found, whereas the cluster belonging to DOCA-MMF group was found to be intermixed. No changes were found at the phylum level among all experimental groups. MMF restored the elevation in lactate-producing bacteria found in DOCA-salt joined to an increase in the acetate-producing bacteria. MMF restored the percentage of anaerobic bacteria in the DOCA-salt group to values similar to control rats. The improvement of gut dysbiosis was associated with an enhanced colonic integrity and a decreased sympathetic drive in the gut. MMF inhibited neuroinflammation in the paraventricular nuclei in the hypothalamus. This study demonstrates for the first time that MMF reduces gut dysbiosis in DOCA-salt hypertension models. This effect seems to be related to its capacity to improve gut integrity due to reduced sympathetic drive in the gut associated with reduced brain neuroinflammation.
PB MDPI
YR 2020
FD 2020-11-28
LK http://hdl.handle.net/10668/3951
UL http://hdl.handle.net/10668/3951
LA en
NO Robles-Vera I, de la Visitación N, Sánchez M, Gómez-Guzmán M, Jiménez R, Moleón J, et al. Mycophenolate Improves Brain-Gut Axis Inducing Remodeling of Gut Microbiota in DOCA-Salt Hypertensive Rats. Antioxidants. 2020 Nov 28;9(12):1199
DS RISalud
RD Apr 11, 2025