%0 Journal Article
%A Robles-Vera, Iñaki
%A de la Visitación, Néstor
%A Sánchez, Manuel
%A Gómez-Guzmán, Manuel
%A Jiménez, Rosario
%A Moleón, Javier
%A González-Correa, Cristina
%A Romero, Miguel
%A Yang, Tao
%A Raizada, Mohan K.
%A Toral, Marta
%A Duarte, Juan
%T Mycophenolate Improves Brain-Gut Axis Inducing Remodeling of Gut Microbiota in DOCA-Salt Hypertensive Rats
%D 2020
%U http://hdl.handle.net/10668/3951
%X Microbiota is involved in the host blood pressure (BP) regulation. The immunosuppressive drug mofetil mycophenolate (MMF) ameliorates hypertension. The present study analyzed whether MMF improves dysbiosis in mineralocorticoid-induced hypertension. Male Wistar rats were assigned to three groups: untreated (CTR), deoxycorticosterone acetate (DOCA)-salt, and DOCA treated with MMF for 4 weeks. MMF treatment reduced systolic BP, improved endothelial dysfunction, and reduced oxidative stress and inflammation in aorta. A clear separation in the gut bacterial community between CTR and DOCA groups was found, whereas the cluster belonging to DOCA-MMF group was found to be intermixed. No changes were found at the phylum level among all experimental groups. MMF restored the elevation in lactate-producing bacteria found in DOCA-salt joined to an increase in the acetate-producing bacteria. MMF restored the percentage of anaerobic bacteria in the DOCA-salt group to values similar to control rats. The improvement of gut dysbiosis was associated with an enhanced colonic integrity and a decreased sympathetic drive in the gut. MMF inhibited neuroinflammation in the paraventricular nuclei in the hypothalamus. This study demonstrates for the first time that MMF reduces gut dysbiosis in DOCA-salt hypertension models. This effect seems to be related to its capacity to improve gut integrity due to reduced sympathetic drive in the gut associated with reduced brain neuroinflammation.
%K Mycophenolate
%K Gut dysbiosis
%K Hypertension
%K Oxidative stress
%K Inflammation
%K (Deoxycorticosterone acetate) DOCA-salt model
%K Hipertensión
%K Microbiota
%K Estrés oxidativo
%K Inflamación
%K Acetato de desoxicorticosterona
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