%0 Journal Article
%A Vazquez-Bourgon, Javier
%A Mayoral-van Son, Jaqueline
%A Gomez-Revuelta, Marcos
%A Juncal-Ruiz, Maria
%A Ortiz-Garcia de la Foz, Víctor
%A Tordesillas-Gutierrez, Diana
%A Ayesa-Arriola, Rosa
%A Bioque, Miquel
%A Crespo-Facorro, Benedicto
%T Treatment Discontinuation Impact on Long-Term (10-Year) Weight Gain and Lipid Metabolism in First-Episode Psychosis: Results From the PAFIP-10 Cohort.
%D 2020
%U http://hdl.handle.net/10668/16148
%X Patients with a first episode of psychosis (FEP) are at higher risk of gaining weight and presenting metabolic disturbances, partly related to antipsychotic exposure. Previous studies suggest that treatment discontinuation might have a positive impact on weight in schizophrenia. The aim of this study was to evaluate the effect of treatment discontinuation on weight and metabolic changes in a FEP cohort. A total of 209 FEP patients and 57 healthy controls were evaluated at study entry and prospectively at 10-year follow-up. Anthropometric measures and, clinical, metabolic, and sociodemographic data were collected. Patients discontinuing antipsychotic treatment presented a significantly lower increase in weight and better metabolic parameter results than those still on antipsychotic treatment at 10-year follow-up. Treatment discontinuation had a positive effect on the weight and metabolic changes observed in FEP patients; however, this effect was not sufficient to reaching a complete reversal to normal levels.
%K Treatment discontinuation
%K lipid metabolism
%K medication-naïve
%K second-generation antipsychotic
%K weight gain
%~