RT Journal Article
T1 Clinical outcome in solid organ transplant recipients affected by COVID-19 compared to general population: a systematic review and meta-analysis.
A1 Gatti, Milo
A1 Rinaldi, Matteo
A1 Bussini, Linda
A1 Bonazzetti, Cecilia
A1 Pascale, Renato
A1 Pasquini, Zeno
A1 Fani, Francesca
A1 Pinho Guedes, Mariana Nunes
A1 Azzini, Anna Maria
A1 Carrara, Elena
A1 Palacios-Baena, Zaira R
A1 Caponcello, Giulia
A1 Reyna-Villasmil, Eduardo
A1 Tacconelli, Evelina
A1 Rodríguez-Baño, Jesús
A1 Viale, Pierluigi
A1 Giannella, Maddalena
K1 30-Day mortality rate
K1 COVID-19
K1 Clinical outcome
K1 Solid organ transplant recipients
K1 Superinfections
AB A significant increased risk of complications and mortality in immunocompromised patients affected by COVID-19 has been described. However, the impact of COVID-19 in solid organ transplant (SOT) recipients is an issue still under debate, due to conflicting evidence that has emerged from different observational studies. We performed a systematic review with a meta-analysis to assess the clinical outcome in SOT recipients with COVID-19 compared with the general population. PubMed-MEDLINE and Scopus were independently searched until 13 October 2021. Prospective or retrospective observational studies comparing clinical outcome in SOT recipients versus general populations affected by COVID-19 were included. The primary endpoint was 30-day mortality. Participants were patients with confirmed COVID-19. Interventions reviewed were SOTs. The quality of the included studies was independently assessed with the Risk of Bias in Non-randomized Studies of Interventions tool for observational studies. The meta-analysis was performed by pooling ORs retrieved from studies providing adjustment for confounders using a random-effects model with the inverse variance method. Multiple subgroups and sensitivity analyses were conducted to investigate the source of heterogeneity. A total of 3501 articles were screened, and 31 observational studies (N = 590 375; 5759 SOT recipients vs. 584 616 general population) were included in the meta-analyses. No difference in 30-day mortality rate was found in the primary analysis, including studies providing adjustment for confounders (N = 17; 3752 SOT recipients vs. 159 745 general population; OR: 1.13; 95% CI, 0.94-1.35; I2 = 33.9%). No evidence of publication bias was reported. A higher risk of intensive care unit admission (OR: 1.56; 95% CI, 1.03-2.63) and occurrence of acute kidney injury (OR: 2.50; 95% CI, 1.81-3.45) was found in SOT recipients. No increased risk in mortality was found in SOT recipients affected by COVID-19 compared with the general population when adjusted for demographic and clinical features and COVID-19 severity.
PB Elsevier Ltd
YR 2022
FD 2022-03-11
LK http://hdl.handle.net/10668/22127
UL http://hdl.handle.net/10668/22127
LA en
NO Gatti M, Rinaldi M, Bussini L, Bonazzetti C, Pascale R, Pasquini Z,  et al. Clinical outcome in solid organ transplant recipients affected by COVID-19 compared to general population: a systematic review and meta-analysis. Clin Microbiol Infect. 2022 Aug;28(8):1057-1065.
DS RISalud
RD Apr 17, 2025