RT Journal Article
T1 Spatial clustering of tuning in mouse primary visual cortex.
A1 Ringach, Dario L
A1 Mineault, Patrick J
A1 Tring, Elaine
A1 Olivas, Nicholas D
A1 Garcia-Junco-Clemente, Pablo
A1 Trachtenberg, Joshua T
K1 Mice, Transgenic
K1 Models, Neurological
K1 Photic Stimulation
K1 Visual Fields
K1 Visual Perception
AB The primary visual cortex of higher mammals is organized into two-dimensional maps, where the preference of cells for stimulus parameters is arranged regularly on the cortical surface. In contrast, the preference of neurons in the rodent appears to be arranged randomly, in what is termed a salt-and-pepper map. Here we revisited the spatial organization of receptive fields in mouse primary visual cortex by measuring the tuning of pyramidal neurons in the joint orientation and spatial frequency domain. We found that the similarity of tuning decreases as a function of cortical distance, revealing a weak but statistically significant spatial clustering. Clustering was also observed across different cortical depths, consistent with a columnar organization. Thus, the mouse visual cortex is not strictly a salt-and-pepper map. At least on a local scale, it resembles a degraded version of the organization seen in higher mammals, hinting at a possible common origin.
PB Nature Publishing Group
YR 2016
FD 2016-08-02
LK https://hdl.handle.net/10668/27554
UL https://hdl.handle.net/10668/27554
LA en
NO Ringach DL, Mineault PJ, Tring E, Olivas ND, Garcia-Junco-Clemente P, Trachtenberg JT. Spatial clustering of tuning in mouse primary visual cortex. Nat Commun. 2016 Aug 2;7:12270.
DS RISalud
RD Apr 5, 2025