TY  - JOUR
AU  - Roca-Ayats, Neus
AU  - Ng, Pei Ying
AU  - Garcia-Giralt, Natalia
AU  - Falco-Mascaro, Maite
AU  - Cozar, Mónica
AU  - Abril, Josep Francesc
AU  - Quesada Gomez, Jose Manuel
AU  - Prieto-Alhambra, Daniel
AU  - Nogues, Xavier
AU  - Dunford, James E
AU  - Russell, R Graham
AU  - Baron, Roland
AU  - Grinberg, Daniel
AU  - Balcells, Susana
AU  - Diez-Perez, Adolfo
PY  - 2018
DO  - 10.1002/jbmr.3580
UR  - http://hdl.handle.net/10668/12910
T2  - Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
AB  - Atypical femoral fractures (AFFs) are a rare but potentially devastating event, often but not always linked to bisphosphonate (BP) therapy. The pathogenic mechanisms underlying AFFs remain obscure, and there are no tests available that might assist in...
LA  - en
PB  - Oxford University Press
KW  - Atypical femoral fractures
KW  - Bisphosphonates
KW  - GGPS1
KW  - WES
KW  - Animals
KW  - Dimethylallyltranstransferase
KW  - Farnesyltranstransferase
KW  - Female
KW  - Femoral Fractures
KW  - Femur
KW  - Geranyltranstransferase
KW  - Humans
KW  - Mice
KW  - Mutation
KW  - RANK Ligand
KW  - RAW 264.7 Cells
KW  - RNA, Small Interfering
KW  - Exome Sequencing
TI  - Functional Characterization of a GGPPS Variant Identified in Atypical Femoral Fracture Patients and Delineation of the Role of GGPPS in Bone-Relevant Cell Types.
TY  - research article
VL  - 33
ER  -