RT Generic
T1 Impact of the Content of Fatty Acids of Oral Fat Tolerance Tests on Postprandial Triglyceridemia: Systematic Review and Meta-Analysis
A1 Monfort-Pires, Milena
A1 Delgado-Lista, Javier
A1 Gomez-Delgado, Francisco
A1 Lopez-Miranda, Jose
A1 Perez-Martinez, Pablo
A1 Gouvea Ferreira, Sandra Roberta
K1 Fat tolerance test
K1 Postprandial triglycerides
K1 Saturated fatty acids
K1 Polyunsaturated fatty acids
K1 Monounsaturated fatty acids
K1 Nonfasting triglycerides
K1 Insulin sensitivity
K1 Olive oil
K1 Men
K1 Lipemia
K1 Dietary
K1 Risk
K1 Meal
K1 Women
K1 Inflammation
AB Whether the content of saturated (SFA), monounsaturated (MUFA), and polyunsaturated fatty acids (PUFA) could differently influence postprandial triglycerides (TG) is unknown. We examined possible differences in the postprandial TG response to fat tolerance tests (FTTs), in which SFA or unsaturated fatty acids were used. Crossover clinical trials investigating the effects of FTTs containing SFA and unsaturated fats on postprandial triglyceridemia in databases from 1994 until 2016 were searched. Of 356 studies, 338 were excluded and 18 were considered. TG net incremental areas under the curve were calculated using time-points or changes from baseline. Pooled effects of standardized mean differences and I-2 test were used. Results: In 12 studies, responses to SFA versus PUFA meals, and in 16 studies versus MUFA meals were compared. Over 4 h, no differences between SFA and unsaturated fats were observed. Over 8 h a lower response to PUFA (SMD -2.28; 95% CI -4.16, -0.41) and a trend to lower response to MUFA (SMD -0.89, 95% CI -1.82, 0.04) were detected. FTTs shorter than 8 h may not be sufficient to differentiate postprandial TG after challenges with distinct fatty acids. Clinical significance of different postprandial TG responses on cardiovascular risk in the long-term deserves investigation.
PB MDPI
YR 2016
FD 2016-09-12
LK http://hdl.handle.net/10668/19308
UL http://hdl.handle.net/10668/19308
LA en
NO Monfort-Pires M, Delgado-Lista J, Gomez-Delgado F, Lopez-Miranda J, Perez-Martinez P, Ferreira SR. Impact of the Content of Fatty Acids of Oral Fat Tolerance Tests on Postprandial Triglyceridemia: Systematic Review and Meta-Analysis. Nutrients. 2016 Sep 21;8(9):580
NO Partly supported by research grants from the São Paulo Research Foundation—FAPESP, Brazil (2012/05487-2; 2012/05503-8 and 2014-08470-9). Partly supported by research grants from the Ministerio de Ciencia e Innovacion (AGL2009-122270 to J.L.-M., FIS PI10/01041 to P P-M, FIS PI13/00023 to J.D.-L.); Ministerio de Economia y Competitividad (AGL2012/39615 to J.L.-M.); Consejeria de Salud, Junta de Andalucia (PI0193/09 to J.L.-M., PI-0252/09 to J.D.-L., and PI-0058/10 to P.P.-M.); Proyecto de Excelencia, Consejería de Economía, Innovación, Ciencia y Empleo (CVI-7450 to J.L.-M.); Francisco Gomez-Delgado is supported by an ISCIII research contract (Programa Rio-Hortega). The CIBEROBN is an initiative of the Instituto de Salud Carlos III, Madrid, Spain.
DS RISalud
RD Apr 9, 2025