RT Journal Article
T1 A comparison of complementary measures of vitamin B6 status, function, and metabolism in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.
A1 Clasen, Joanna L
A1 Heath, Alicia K
A1 Van Puyvelde, Heleen
A1 Huybrechts, Inge
A1 Park, Jin Young
A1 Ferrari, Pietro
A1 Johansson, Mattias
A1 Scelo, Ghislaine
A1 Ulvik, Arve
A1 Midttun, Øivind
A1 Ueland, Per Magne
A1 Dahm, Christina C
A1 Halkjær, Jytte
A1 Olsen, Anja
A1 Johnson, Theron
A1 Katzke, Verena
A1 Schulze, Matthias B
A1 Masala, Giovanna
A1 Segrado, Francesco
A1 de Magistris, Maria Santucci
A1 Sacerdote, Carlotta
A1 Ocké, Marga C
A1 Luján-Barroso, Leila
A1 Ching-López, Ana
A1 Huerta, José María
A1 Ardanaz, Eva
A1 Amiano, Pilar
A1 Ericson, Ulrika
A1 Manjer, Jonas
A1 Gylling, Björn
A1 Johansson, Ingegerd
A1 Schmidt, Julie
A1 Weiderpass, Elisabete
A1 Riboli, Elio
A1 Cross, Amanda J
A1 Muller, David C
K1 PLP
K1 dietary biomarkers
K1 kynurenine pathway
K1 transsulfuration pathway
K1 vitamin B6
AB Vitamin B6 insufficiency has been linked to increased risk of cancer and other chronic diseases. The circulating concentration of pyridoxal 5'-phosphate (PLP) is a commonly used measure of vitamin B6 status. Ratios of substrates indicating PLP coenzymatic function and metabolism may be useful complementary measures to further explore the role of vitamin B6 in health. We explored the sensitivity of 5 outcomes, namely PLP concentration, homocysteine:cysteine (Hcy:Cys), cystathionine:cysteine (Cysta:Cys), the 3´-hydroxykynurenine ratio (HKr), and the 4-pyridoxic acid ratio (PAr) to vitamin B6 intake as well as personal and lifestyle characteristics. Dietary intake and biomarker data were collected from participants from 3 nested case-control studies within the European Prospective Investigation into Cancer and Nutrition (EPIC). Bayesian regression models assessed the associations of the 5 biomarker outcomes with vitamin B6 intake and personal and lifestyle covariates. Analogous models examined the relations of Hcy:Cys, Cysta:Cys, and HKr with PLP. In total, 4608 participants were included in the analyses. Vitamin B6 intake was most strongly associated with PLP, moderately associated with Hcy:Cys, Cysta:Cys, and HKr, and not associated with PAr (fold change in marker given a doubling of vitamin B6 intake: PLP 1.60 [95% credible interval (CrI): 1.50, 1.71]; Hcy:Cys 0.87 [95% CrI: 0.84, 0.90]; Cysta:Cys 0.89 [95% CrI: 0.84, 0.94]; HKr 0.88 [95% CrI: 0.85, 0.91]; PAr 1.00 [95% CrI: 0.95, 1.05]). PAr was most sensitive to age, and HKr was least sensitive to BMI and alcohol intake. Sex and menopause status were strongly associated with all 5 markers. We found that 5 different markers, capturing different aspects of vitamin B6-related biological processes, varied in their associations with vitamin B6 intake and personal and lifestyle predictors.
PB American Society of Clinical Nutrition
YR 2021
FD 2021
LK http://hdl.handle.net/10668/17541
UL http://hdl.handle.net/10668/17541
LA en
NO Clasen JL, Heath AK, Van Puyvelde H, Huybrechts I, Park JY, Ferrari P, et al. A comparison of complementary measures of vitamin B6 status, function, and metabolism in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Am J Clin Nutr. 2021 Jul 1;114(1):338-347
DS RISalud
RD Apr 7, 2025