RT Journal Article
T1 Mesenchymal Stromal Cell-Conditioned Medium for Skin Diseases: A Systematic Review
A1 Montero-Vilchez, Trinidad
A1 Sierra-Sánchez, Álvaro
A1 Sanchez-Diaz, Manuel
A1 Quiñones-Vico, Maria Isabel
A1 Sanabria-de-la-Torre, Raquel
A1 Martinez-Lopez, Antonio
A1 Arias-Santiago, Salvador
K1 Advanced therapy
K1 Conditioned medium
K1 Dermatology
K1 Mesenchymal stem cells
K1 Stem cells
K1 Medios de cultivo condicionados
K1 Dermatología
K1 Células madre mesenquimatosas
AB The skin is the largest organ of the human body, and its dysfunction is related to many diseases. There is a need to find new potential effective therapies for some skin conditions such as inflammatory diseases, wound healing, or hair restoration. Mesenchymal stromal cell (MSC)-conditioned medium (CM) provides a potential opportunity in the treatment of skin disease. Thus, the objective of this review is to evaluate the uses of MSC-CM for treating skin diseases in both animal and human models. A systematic review was conducted regarding the use of MSC-CM for treating skin conditions. One hundred one studies were analyzed. MSC-CM was evaluated in wound healing (55), hypertrophic scars (9), flap reperfusion (4), hair restoration (15), skin rejuvenation (15), and inflammatory skin diseases (3). MSC-CM was obtained from different MSC sources, mainly adipose tissue, bone marrow, and umbilical cord blood. MSC-CM was tested intravenously, intraperitoneally, subcutaneously, intradermally or intralesionally injected or topically applied. MSC-CM was used in both animals and humans. MSC-CM improved wound healing, hair restoration, skin rejuvenation, atopic dermatitis, and psoriasis in both animals and humans. MSC-CM also decreased hypertrophic scars and flap ischemia in animal models. In conclusion, MSC-CM is a promising therapy for skin conditions. Further studies are needed to corroborate safety and effectiveness and to standardize CM manufacturing.
PB Frontiers
YR 2021
FD 2021-07-23
LK http://hdl.handle.net/10668/4150
UL http://hdl.handle.net/10668/4150
LA en
NO Montero-Vilchez T, Sierra-Sánchez Á, Sanchez-Diaz M, Quiñones-Vico MI, Sanabria-de-la-Torre R, Martinez-Lopez A, et al. Mesenchymal Stromal Cell-Conditioned Medium for Skin Diseases: A Systematic Review. Front Cell Dev Biol. 2021 Jul 23;9:654210
DS RISalud
RD Apr 8, 2025