%0 Journal Article
%A Montero-Vilchez, Trinidad
%A Sierra-Sánchez, Álvaro
%A Sanchez-Diaz, Manuel
%A Quiñones-Vico, Maria Isabel
%A Sanabria-de-la-Torre, Raquel
%A Martinez-Lopez, Antonio
%A Arias-Santiago, Salvador
%T Mesenchymal Stromal Cell-Conditioned Medium for Skin Diseases: A Systematic Review
%D 2021
%U http://hdl.handle.net/10668/4150
%X The skin is the largest organ of the human body, and its dysfunction is related to many diseases. There is a need to find new potential effective therapies for some skin conditions such as inflammatory diseases, wound healing, or hair restoration. Mesenchymal stromal cell (MSC)-conditioned medium (CM) provides a potential opportunity in the treatment of skin disease. Thus, the objective of this review is to evaluate the uses of MSC-CM for treating skin diseases in both animal and human models. A systematic review was conducted regarding the use of MSC-CM for treating skin conditions. One hundred one studies were analyzed. MSC-CM was evaluated in wound healing (55), hypertrophic scars (9), flap reperfusion (4), hair restoration (15), skin rejuvenation (15), and inflammatory skin diseases (3). MSC-CM was obtained from different MSC sources, mainly adipose tissue, bone marrow, and umbilical cord blood. MSC-CM was tested intravenously, intraperitoneally, subcutaneously, intradermally or intralesionally injected or topically applied. MSC-CM was used in both animals and humans. MSC-CM improved wound healing, hair restoration, skin rejuvenation, atopic dermatitis, and psoriasis in both animals and humans. MSC-CM also decreased hypertrophic scars and flap ischemia in animal models. In conclusion, MSC-CM is a promising therapy for skin conditions. Further studies are needed to corroborate safety and effectiveness and to standardize CM manufacturing.
%K Advanced therapy
%K Conditioned medium
%K Dermatology
%K Mesenchymal stem cells
%K Stem cells
%K Medios de cultivo condicionados
%K Dermatología
%K Células madre mesenquimatosas
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