RT Journal Article
T1 Towards Precision Medicine in Psychosis: Benefits and Challenges of Multimodal Multicenter Studies-PSYSCAN: Translating Neuroimaging Findings From Research into Clinical Practice.
A1 Tognin, Stefania
A1 van Hell, Hendrika H
A1 Merritt, Kate
A1 Winter-van Rossum, Inge
A1 Bossong, Matthijs G
A1 Kempton, Matthew J
A1 Modinos, Gemma
A1 Fusar-Poli, Paolo
A1 Mechelli, Andrea
A1 Dazzan, Paola
A1 Maat, Arija
A1 de Haan, Lieuwe
A1 Crespo-Facorro, Benedicto
A1 Glenthøj, Birte
A1 Lawrie, Stephen M
A1 McDonald, Colm
A1 Gruber, Oliver
A1 van Amelsvoort, Therese
A1 Arango, Celso
A1 Kircher, Tilo
A1 Nelson, Barnaby
A1 Galderisi, Silvana
A1 Bressan, Rodrigo
A1 Kwon, Jun S
A1 Weiser, Mark
A1 Mizrahi, Romina
A1 Sachs, Gabriele
A1 Maatz, Anke
A1 Kahn, René
A1 McGuire, Phillip
A1 PSYSCAN Consortium, 
K1 MRI
K1 PSYSCAN
K1 clinical high risk of psychosis
K1 first episode of psychosis
K1 machine learning
K1 neuroimaging
K1 prediction
K1 psychosis
AB In the last 2 decades, several neuroimaging studies investigated brain abnormalities associated with the early stages of psychosis in the hope that these could aid the prediction of onset and clinical outcome. Despite advancements in the field, neuroimaging has yet to deliver. This is in part explained by the use of univariate analytical techniques, small samples and lack of statistical power, lack of external validation of potential biomarkers, and lack of integration of nonimaging measures (eg, genetic, clinical, cognitive data). PSYSCAN is an international, longitudinal, multicenter study on the early stages of psychosis which uses machine learning techniques to analyze imaging, clinical, cognitive, and biological data with the aim of facilitating the prediction of psychosis onset and outcome. In this article, we provide an overview of the PSYSCAN protocol and we discuss benefits and methodological challenges of large multicenter studies that employ neuroimaging measures.
YR 2020
FD 2020
LK http://hdl.handle.net/10668/14408
UL http://hdl.handle.net/10668/14408
LA en
DS RISalud
RD Apr 11, 2025