RT Journal Article
T1 Repercussions of Bisphenol A on the Physiology of Human Osteoblasts.
A1 Garcia-Recio, Enrique
A1 Costela-Ruiz, Victor J
A1 Melguizo-Rodriguez, Lucia
A1 Ramos-Torrecillas, Javier
A1 Garcia-Martinez, Olga
A1 Ruiz, Concepcion
A1 de Luna-Bertos, Elvira
K1 Bisphenol A
K1 bone tissue
K1 cellular differentiation
K1 cellular viability
K1 osteoblast
AB (1) Background: Bisphenol A (BPA) is an endocrine disruptor that is widely present in the environment and exerts adverse effects on various body tissues. The objective of this study was to determine its repercussions on bone tissue by examining its impact on selected functional parameters of human osteoblasts. (2) Methods: Three human osteoblast lines were treated with BPA at doses of 10-5, 10-6, or 10-7 M. At 24 h post-treatment, a dose-dependent inhibition of cell growth, alkaline phosphatase activity, and mineralization was observed. (4) Results: The expression of CD54 and CD80 antigens was increased at doses of 10-5 and 10-6 M, while the phagocytic capacity and the expression of osteogenic genes (ALP, COL-1, OSC, RUNX2, OSX, BMP-2, and BMP-7) were significantly and dose-dependently reduced in the presence of BPA. (5) Conclusions: According to these findings, BPA exerts adverse effects on osteoblasts by altering their differentiation/maturation and their proliferative and functional capacity, potentially affecting bone health. Given the widespread exposure to this contaminant, further human studies are warranted to determine the long-term risk to bone health posed by BPA.
PB MDPI AG
YR 2022
FD 2022-05-09
LK http://hdl.handle.net/10668/21156
UL http://hdl.handle.net/10668/21156
LA en
NO García-Recio E, Costela-Ruiz VJ, Melguizo-Rodriguez L, Ramos-Torrecillas J, García-Martínez O, Ruiz C, et al. Repercussions of Bisphenol A on the Physiology of Human Osteoblasts. Int J Mol Sci. 2022 May 11;23(10):5349.
DS RISalud
RD Apr 9, 2025