RT Journal Article
T1 Prognostic and Clinicopathological Significance of CCND1/Cyclin D1 Upregulation in Melanomas: A Systematic Review and Comprehensive Meta-Analysis.
A1 González-Ruiz, Lucía
A1 González-Moles, Miguel Ángel
A1 González-Ruiz, Isabel
A1 Ruiz-Ávila, Isabel
A1 Ramos-García, Pablo
K1 CCND1
K1 cyclin D1
K1 melanoma
K1 meta-analysis
K1 systematic review
AB Our objective was to evaluate the prognostic and clinicopathological significance of cyclin D1 (CD1) overexpression/CCND1 amplification in melanomas. We searched studies published before September 2019 (PubMed, Embase, Web of Science, Scopus). We evaluated the quality of the studies included (QUIPS tool). The impact of CD1 overexpression/CCND1 amplification on overall survival and relevant clinicopathological characteristic were meta-analyzed. We performed heterogeneity, sensitivity, small-study effects, and subgroup analyses. Forty-one studies and 3451 patients met inclusion criteria. Qualitative evaluation demonstrated that not all studies were performed with the same rigor, finding the greatest risk of bias in the study confounding domain. Quantitative evaluation showed that immunohistochemical CD1 overexpression had a statistical association with Breslow thickness (p = 0.007; OR = 2.09,95% CI = 1.23-3.57), significantly higher frequency of CCND1/cyclin D1 abnormalities has been observed in the primary tumor compared to distant metastases (p = 0.004), revealed also by immunohistochemical overexpression of the protein (p
SN 2072-6694
YR 2021
FD 2021-03-15
LK https://hdl.handle.net/10668/28171
UL https://hdl.handle.net/10668/28171
LA en
DS RISalud
RD Apr 8, 2025