RT Journal Article
T1 Identifying comorbidities and lifestyle factors contributing to the cognitive profile of early Parkinson's disease.
A1 Martinez-Horta, Saul
A1 Bejr-Kasem, Helena
A1 Horta-Barba, Andrea
A1 Pascual-Sedano, Berta
A1 Santos-Garcia, Diego
A1 de Deus-Fonticoba, Teresa
A1 Jesus, Silvia
A1 Aguilar, Miquel
A1 Planellas, Lluis
A1 Garcia-Caldentey, Juan
A1 Caballol, Nuria
A1 Vives-Pastor, Barbara
A1 Hernandez-Vara, Jorge
A1 Cabo-Lopez, Iria
A1 Lopez-Manzanares, Lydia
A1 Gonzalez-Aramburu, Isabel
A1 Avila-Rivera, Maria Asuncion
A1 Catalan, Maria Jose
A1 Lopez-Diaz, Luis Manuel
A1 Puente, Victor
A1 Garcia-Moreno, Jose Manuel
A1 Borrue, Carmen
A1 Solano-Vila, Berta
A1 Alvarez-Sauco, Maria
A1 Vela, Lydia
A1 Escalante, Sonia
A1 Cubo, Esther
A1 Carrillo-Padilla, Francisco
A1 Martinez-Castrillo, Juan Carlos
A1 Sanchez-Alonso, Pilar
A1 Alonso-Losada, Maria Gema
A1 Lopez-Ariztegui, Nuria
A1 Gaston, Itziar
A1 Blazquez-Estrada, Marta
A1 Seijo-Martinez, Manual
A1 Ruiz-Martinez, Javier
A1 Valero-Merino, Caridad
A1 Kurtis, Monica
A1 de Fabregues-Boixar, Oriol
A1 Gonzalez-Ardura, Jessica
A1 Prieto-Jurczynska, Cristina
A1 Martinez-Martin, Pablo
A1 Mir, Pablo
A1 Kulisevsky, Jaime
K1 Cognition
K1 Coppadis
K1 Lifestyle
K1 PD-MCI
K1 Parkinson’s disease
AB Identifying modifiable risk factors for cognitive impairment in the early stages of Parkinson's disease (PD) and estimating their impact on cognitive status may help prevent dementia (PDD) and the design of cognitive trials. Using a standard approach for the assessment of global cognition in PD and controlling for the effects of age, education and disease duration, we explored the associations between cognitive status, comorbidities, metabolic variables and lifestyle variables in 533 PD participants from the COPPADIS study. Among the overall sample, 21% of participants were classified as PD-MCI (n = 114) and 4% as PDD (n = 26). The prevalence of hypertension, diabetes and dyslipidemia was significantly higher in cognitively impaired patients while no between-group differences were found for smoking, alcohol intake or use of supplementary vitamins. Better cognitive scores were significantly associated with regular physical exercise (p  We extend previous findings regarding the positive and negative influence of various comorbidities and lifestyle factors on cognitive status in early PD patients, and reinforce the need to identify and treat potentially modifiable variables with the intention of exploring the possible improvement of the global cognitive status of patients with PD.
PB BioMed Central Ltd.
YR 2021
FD 2021-12-08
LK https://hdl.handle.net/10668/27945
UL https://hdl.handle.net/10668/27945
LA en
NO Martínez-Horta S, Bejr-Kasem H, Horta-Barba A, Pascual-Sedano B, Santos-García D, de Deus-Fonticoba T, et al. Identifying comorbidities and lifestyle factors contributing to the cognitive profile of early Parkinson's disease. BMC Neurol. 2021 Dec 8;21(1):477.
DS RISalud
RD Apr 5, 2025