RT Journal Article
T1 Mediterranean Diet and Telomere Length: A Systematic Review and Meta-Analysis.
A1 Canudas, Silvia
A1 Becerra-Tomas, Nerea
A1 Hernandez-Alonso, Pablo
A1 Galie, Serena
A1 Leung, Cindy
A1 Crous-Bou, Marta
A1 De Vivo, Immaculata
A1 Gao, Yawen
A1 Gu, Yian
A1 Meinilä, Jelena
A1 Milte, Catherine
A1 García-Calzon, Sonia
A1 Marti, Amelia
A1 Boccardi, Virginia
A1 Ventura-Marra, Melissa
A1 Salas-Salvado, Jordi
K1 Mediterranean diet
K1 Accelerated telomere shortening
K1 Age-associated diseases
K1 Dietary pattern
K1 Healthy aging
K1 Telomere length
AB Accelerated telomere shortening has been associated with several age-related diseases and/or decreased lifespan in humans. The Mediterranean diet (MedDiet) is considered to be 1 of the most recognized diets for disease prevention and healthy aging, partially due to its demonstrated anti-inflammatory and antioxidative properties which may impact on telomere length (TL). The aim of this meta-analysis was to determine the associations between MedDiet adherence and TL maintenance. MEDLINE-PubMed and Cochrane databases were searched up to December 2018 for studies evaluating the association between MedDiet adherence and TL in blood cells. Two reviewers, working independently, screened all titles and abstracts to identify studies that met the inclusion criteria [cross-sectional, case-control, and prospective cohort studies and randomized clinical trials (RCTs) published in English and excluded nonoriginal articles]. Data were pooled by the generic inverse variance method using the random effects model and expressed as standardized mean difference (SMD). Heterogeneity was identified using the Cochran Q test and quantified by the I2 statistic. A total of 8 original cross-sectional studies were included for the quantitative meta-analysis, comprising a total of 13,733 participants from 5 countries. A positive association between adherence to the MedDiet and TL was observed in all meta-analyses, with the exception of those conducted only in men: SMD (95% CI) of 0.130 (0.029; 0.231) for all subjects, 0.078 (0.005; 0.152) for women, and 0.095 (-0.005; 0.195) for men. Only 1 prospective cohort study and 1 RCT were identified, therefore, we could not undertake a meta-analysis for these study designs. The present meta-analysis of cross-sectional studies demonstrates that higher MedDiet adherence is associated with longer TL. At the same time, larger and high-quality prospective studies and clinical trials are warranted to confirm this association.
PB Elsevier
YR 2020
FD 2020
LK http://hdl.handle.net/10668/16028
UL http://hdl.handle.net/10668/16028
LA en
NO Canudas S, Becerra-Tomás N, Hernández-Alonso P, Galié S, Leung C, Crous-Bou M, De Vivo I, et al. Mediterranean Diet and Telomere Length: A Systematic Review and Meta-Analysis. Adv Nutr. 2020 Nov 16;11(6):1544-1554
DS RISalud
RD May 11, 2025