TY - JOUR AU - Bueno, Clara AU - Calero-Nieto, Fernando J AU - Wang, Xiaonan AU - Valdés-Mas, Rafael AU - Gutiérrez-Agüera, Francisco AU - Roca-Ho, Heleia AU - Ayllon, Veronica AU - Real, Pedro J AU - Arambilet, David AU - Espinosa, Lluis AU - Torres-Ruiz, Raul AU - Agraz-Doblas, Antonio AU - Varela, Ignacio AU - de Boer, Jasper AU - Bigas, Anna AU - Gottgens, Bertie AU - Marschalek, Rolf AU - Menendez, Pablo PY - 2019 DO - 10.3324/haematol.2018.202044 UR - http://hdl.handle.net/10668/13459 T2 - Haematologica AB - The t(4;11)(q21;q23) translocation is associated with high-risk infant pro-B-cell acute lymphoblastic leukemia and arises prenatally during embryonic/fetal hematopoiesis. The developmental/pathogenic contribution of the t(4;11)-resulting MLL-AF4 (MA4)... LA - en KW - Animals KW - Apoptosis KW - Cell Cycle KW - Cell Differentiation KW - Coculture Techniques KW - Embryonic Development KW - Endothelial Cells KW - Hematopoiesis KW - Hematopoietic Stem Cells KW - Histones KW - Human Embryonic Stem Cells KW - Humans KW - Methylation KW - Mice KW - Mice, Knockout KW - Myeloid-Lymphoid Leukemia Protein KW - Oncogene Proteins, Fusion TI - Enhanced hemato-endothelial specification during human embryonic differentiation through developmental cooperation between AF4-MLL and MLL-AF4 fusions. TY - research article VL - 104 ER -