%0 Journal Article
%A Cuevas, Belén
%A Arroba, Ana I.
%A de los Reyes, Carolina
%A Gómez-Jaramillo, Laura
%A González-Montelongo, M. Carmen
%A Zubía, Eva
%T Diterpenoids from the Brown Alga Rugulopteryx okamurae and Their Anti-Inflammatory Activity
%D 2021
%U http://hdl.handle.net/10668/4521
%X Brown algae of the Family Dictyotaceae produce an array of structurally diverse terpenoids, whose biomedical potential in the anti-inflammatory area has been scarcely explored. Herein, the chemical study of the alga Rugulopteryx okamurae has led to the isolation of ten new diterpenoids: rugukadiol A (1), rugukamurals A-C (2-4), and ruguloptones A-F (6-10). The structures of the new compounds were established by spectroscopic means. Compound 1 exhibits an unprecedented diterpenoid skeleton featuring a bridged tricyclic undecane system. Compounds 2-10 belong to the secospatane class of diterpenoids and differ by the oxygenated functions that they contain. In anti-inflammatory assays, the new diterpenoid 1 and the secospatanes 5 and 10 significantly inhibited the production of the inflammatory mediator NO in LPS-stimulated microglial cells Bv.2 and macrophage cells RAW 264.7. Moreover, compounds 1 and 5 were found to strongly inhibit the expression of Nos2 and the pro-inflammatory cytokine Il1b in both immune cell lines.
%K Diterpenoids
%K Brown algae
%K Rugulopteryx okamurae
%K Anti-inflammatory
%K Nitric oxide
%K Cytokine
%K Microglia
%K Macrophages
%K Invasive algae
%K Diterpenos
%K Phaeophyta
%K Algas marinas
%K Antiinflamatorios
%K Óxido nítrico
%K Citocinas
%K Macrófagos
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