RT Journal Article
T1 Clusters of inflammation in COVID-19: descriptive analysis and prognosis on more than 15,000 patients from the Spanish SEMI-COVID-19 Registry.
A1 Rubio-Rivas, Manuel
A1 Mora-Lujan, Jose Maria
A1 Formiga, Francesc
A1 Corrales-Gonzalez, Miguel Angel
A1 Garcia-Andreu, Maria Del Mar
A1 Moreno-Torres, Victor
A1 Garcia-Garcia, Gema Maria
A1 Alcala-Pedrajas, Jose N
A1 Boixeda, Ramon
A1 Perez-Lluna, Leticia
A1 Cortes-Rodriguez, Begoña
A1 Mella-Perez, Carmen
A1 Navas-Alcantara, Maria de la Sierra
A1 Lopez-Reboiro, Manuel Lorenzo
A1 Alfaro-Lara, Veronica
A1 Perez-Martin, Santiago
A1 Martin-Oterino, Jose Angel
A1 Gracia-Gutierrez, Anyuli
A1 Martin-Urda Diez-Canseco, Anabel
A1 Comas-Casanova, Pere
A1 Perez-Garcia, Cristina
A1 Varona, Jose F
A1 Gómez-Huelgas, Ricardo
A1 Anton-Santos, Juan-Miguel
A1 Lumbreras-Bermejo, Carlos
K1 COVID-19
K1 Cluster analysis
K1 Coronavirus
K1 Inflammation
K1 Mortality
K1 Prognosis
K1 Área de Gestión Sanitaria Sur de Córdoba
K1 Área de Gestión Sanitaria Norte de Córdoba
AB Uncontrolled infammation following COVID-19 infection is an important characteristic of the most seriously ill patients. The present study aims to describe the clusters of infammation in COVID-19 and to analyze their prognostic role. This is a retrospective observational study including 15,691 patients with a high degree of infammation. They were included in the Spanish SEMI-COVID-19 registry from March 1, 2020 to May 1, 2021. The primary outcome was in-hospital mortality. Hierarchical cluster analysis identifed 7 clusters. C1 is characterized by lymphopenia, C2 by elevated ferritin, and C3 by elevated LDH. C4 is characterized by lymphopenia plus elevated CRP and LDH and frequently also ferritin. C5 is defned by elevated CRP, and C6 by elevated ferritin and D-dimer, and frequently also elevated CRP and LDH. Finally, C7 is characterized by an elevated D-dimer. The clusters with the highest in-hospital mortality were C4, C6, and C7 (17.4% vs. 18% vs. 15.6% vs. 36.8% vs. 17.5% vs. 39.3% vs. 26.4%). Infammation clusters were found as independent factors for inhospital mortality. In detail and, having cluster C1 as reference, the model revealed a worse prognosis for all other clusters: C2 (OR=1.30, p=0.001), C3 (OR=1.14, p=0.178), C4 (OR=2.28, p<0.001), C5 (OR=1.07, p=0.479), C6 (OR=2.29, p<0.001), and C7 (OR=1.28, p=0.001). We identifed 7 groups based on the presence of lymphopenia, elevated CRP, LDH, ferritin, and D-dimer at the time of hospital admission for COVID-19. Clusters C4 (lymphopenia+LDH+CRP), C6 (ferritin+D-dimer), and C7 (D-dimer) had the worst prognosis in terms of in-hospital mortality.
PB Springer
YR 2021
FD 2021-12-30
LK http://hdl.handle.net/10668/20897
UL http://hdl.handle.net/10668/20897
LA en
NO Rubio-Rivas M, Mora-Luján JM, Formiga F, Corrales González MÁ, García Andreu MDM, Moreno-Torres V, et al. Clusters of inflammation in COVID-19: descriptive analysis and prognosis on more than 15,000 patients from the Spanish SEMI-COVID-19 Registry. Intern Emerg Med. 2022 Jun;17(4):1115-1127
DS RISalud
RD Apr 17, 2025