RT Journal Article
T1 Determination of oleanolic acid in human plasma and its association with olive oil intake in healthy Spanish adults within the EPIC Spain cohort study
A1 Buckland, Genevieve
A1 Pastor, Antoni
A1 Lujan-Barroso, Leila
A1 Alberto Gonzalez, Carlos
A1 Travier, Noemie
A1 Amiano, Pilar
A1 Maria Huerta, Jose
A1 Agudo, Antonio
A1 Navarro, Carmen
A1 Dolores Chirlaque, Maria
A1 Sanchez-Perez, Maria-Jose
A1 Rodriguez-Barranco, Miguel
A1 Barricarte, Aurelio
A1 Ardanaz, Eva
A1 Dorronsoro, Miren
A1 Molinuevo, Amaia
A1 Ramon Quiros, Jose
A1 de la Torre, Rafael
K1 Biomarker
K1 Oleanolic acid
K1 Olive oil
K1 EPIC cohort study
K1 Cancer
K1 Hydroxytyrosol
K1 Triterpenes
K1 Disposition
K1 Apoptosis
K1 Project
K1 Risk
AB Scope: Oleanolic acid (OA) is an important triterpenic compound found in olive oil, however little is known about its concentrations in human plasma. We aimed to determine plasma OA levels in a healthy Spanish population and compare them with estimates of dietary olive oil intake.Methods and results: The final study sample included 141 individuals randomly selected from the European Prospective Investigation into Cancer and Nutrition Spanish cohort. Dietary olive oil intake was estimated using validated dietary history questionnaires. OA concentrations were determined in plasma (from the participants' stored blood samples) using a HPLC-MSmethod. Correlation coefficients between OA and olive oil intake were calculated, adjusting for center; sex; age; consumption of olives, apples, grapes, and red wine; and fasting state. The mean OA concentration in olive oil nonconsumers was 0.72 ng/mL (SD 0.82), while in the high olive oil intake group it was 1.32 ng/mL (SD 1.14). The fully adjusted partial Spearman correlations coefficients reached 0.36 (p-value
PB Wiley
SN 1613-4125
YR 2017
FD 2017-08-01
LK http://hdl.handle.net/10668/18615
UL http://hdl.handle.net/10668/18615
LA en
NO Buckland G, Pastor A, Lujan-Barroso L, Gonzalez CA, Travier N, Amiano P, et al.  Determination of oleanolic acid in human plasma and its association with olive oil intake in healthy Spanish adults within the EPIC Spain cohort study. Mol Nutr Food Res. 2017 Aug;61(8)
DS RISalud
RD Apr 6, 2025