RT Journal Article
T1 First-Line Biological Agents Plus Chemotherapy in Older Patients with Metastatic Colorectal Cancer: A Retrospective Pooled Analysis.
A1 Garcia-Alfonso, Pilar
A1 Diaz-Rubio, Eduardo
A1 Abad, Albert
A1 Carrato, Alfredo
A1 Massuti, Bartomeu
A1 Ortiz-Morales, Maria Jose
A1 Manzano Mozo, Jose Luis
A1 Muñoz, Andres
A1 Duran, Gema
A1 Sastre, Javier
A1 Safont, Maria Jose
A1 Ferreiro, Reyes
A1 Rivera, Fernando
A1 Gonzalez, Encarnacion
A1 Valladares-Ayerbes, Manuel
A1 Gravalos, Cristina
A1 Alonso-Orduña, Vicente
A1 Vieitez, Jose Maria
A1 Yubero, Alfonso
A1 Aranda, Enrique
K1 Colorectal Neoplasms
K1 Panitumumab
K1 Retrospective Studies
AB Biologicals, in combination with chemotherapy, are recommended as first-line treatment of metastatic colorectal cancer (mCRC); however, evidence guiding the appropriate management of older patients with mCRC is limited. This study was undertaken to compare the efficacy and safety outcomes in older versus younger patients with mCRC who received first-line biological therapy. This retrospective analysis used pooled data from five trials undertaken by the Spanish Cooperative Group for the Treatment of Digestive Tumours. All were studies of adults with advanced CRC who received first-line treatment with chemotherapy plus bevacizumab, cetuximab or panitumumab, stratified by age (≥ 65 vs.  In total, 999 patients from five studies were included in the analysis: 480 (48%) were aged ≥ 65 years, and 519 (52%) were aged  Biologicals plus chemotherapy is an effective first-line treatment option for selected patients aged ≥ 65 years with mCRC and has a manageable safety profile and efficacy comparable to that observed in younger patients.
PB Adis International
YR 2021
FD 2021-01-07
LK http://hdl.handle.net/10668/17214
UL http://hdl.handle.net/10668/17214
LA en
NO García-Alfonso P, Díaz-Rubio E, Abad A, Carrato A, Massutí B, Ortiz-Morales MJ, et al. First-Line Biological Agents Plus Chemotherapy in Older Patients with Metastatic Colorectal Cancer: A Retrospective Pooled Analysis. Drugs Aging. 2021 Mar;38(3):219-231
DS RISalud
RD Apr 8, 2025