RT Journal Article
T1 A Systematic Comparative Study of the Toxicity of Semiconductor and Graphitic Carbon-Based Quantum Dots Using In Vitro Cell Models
A1 Navarro-Ruiz, Maria Carmen
A1 Cayuela, Angelina
A1 Soriano, María Laura
A1 Guzmán-Ruiz, Rocio
A1 Malagón, Maria M.
A1 Valcárcel, Miguel
K1 Carbon-based quantum dots
K1 Semiconductor quantum dots
K1 Cellviability
K1 Fibroblasts
K1 Hepatocytes
K1 Fibroblastos
K1 Hepatocitos
K1 Supervivencia celular
K1 Toxicidad
K1 Puntos cuánticos
AB A comparative, fully parallel study of nanoparticles (NPs) toxicity by in vitro cell viability is shown looking for reliable comparability of nanotoxicological results, a well-recognized bottleneck in the context. This procedure is suitable to compare toxicity of similar NPs, as well as the influence on toxicity of the size, surface, and other characteristics. As a case of study, semiconductor (SQDs) and graphitic-carbon quantum dots (CQDs) with identical surface groups and size were evaluated. All experiments were conducted at same conditions, involving two types of cells (mouse fibroblasts (3T3-L1) and carcinoma human hepatocellular cells (HepG2)) and different extracellular components (in the absence or presence of fetal bovine serum (FBS)). Cell viability demonstrated the excellent biocompatibility of CQDs compared to SQDs, which caused higher percentage of cell death at lower concentrations, as predicted but never clearly demonstrated. However, our comparative studies established that the toxicity of SQDs and CQDs are cellular type-dependent, and the absence or presence of serum proteins reduces the minimal concentration necessary of NPs to produce toxicity.
PB MDPI AG
YR 2020
FD 2020-12-10
LK http://hdl.handle.net/10668/3474
UL http://hdl.handle.net/10668/3474
LA en
NO Navarro-Ruiz MC, Cayuela A, Soriano ML, Guzmán-Ruiz R, Malagón MM, Valcárcel M. A Systematic Comparative Study of the Toxicity of Semiconductor and Graphitic Carbon-Based Quantum Dots Using In Vitro Cell Models. Applied Sciences. 2020 Dec 10;10(24):8845.
DS RISalud
RD Apr 6, 2025