RT Journal Article
T1 Prevalence and Clinical Characteristics of SARS-CoV-2 Confirmed and Negative Kawasaki Disease Patients During the Pandemic in Spain.
A1 Fernandez-Cooke, Elisa
A1 Grasa, Carlos D
A1 Dominguez-Rodriguez, Sara
A1 Barrios-Tascon, Ana
A1 Sanchez-Manubens, Judith
A1 Anton, Jordi
A1 Mercader, Beatriz
A1 Villalobos, Enrique
A1 Camacho, Marisol
A1 Navarro-Gomez, Maria Luisa
A1 Oltra-Benavent, Manuel
A1 Giralt, Gemma
A1 Bustillo, Matilde
A1 Bello-Naranjo, Ana Maria
A1 Rocandio, Beatriz
A1 Rodriguez-Gonzalez, Moises
A1 Nuñez-Cuadros, Esmeralda
A1 Aracil-Santos, Javier
A1 Moreno, David
A1 Calvo, Cristina
K1 COVID-19
K1 Kawasaki disease (KD)
K1 SARS-CoV-2
K1 Children
K1 Multisystem inflammatory syndrome in children (MIS-C)
K1 Pediatric inflammatory multisystem syndrome (PIMS-TS)
K1 Shock
AB Introduction: COVID-19 has a less severe course in children. In April 2020, some children presented with signs of multisystem inflammation with clinical signs overlapping with Kawasaki disease (KD), most of them requiring admission to the pediatric intensive care unit (PICU). This study aimed to describe the prevalence and clinical characteristics of KD SARS-CoV-2 confirmed and negative patients during the pandemic in Spain. Material and Methods: Medical data of KD patients from January 1, 2018 until May 30, 2020 was collected from the KAWA-RACE study group. We compared the KD cases diagnosed during the COVID-19 period (March 1-May 30, 2020) that were either SARS-CoV-2 confirmed (CoV+) or negative (CoV-) to those from the same period during 2018 and 2019 (PreCoV). Results: One hundred and twenty-four cases were collected. There was a significant increase in cases and PICU admissions in 2020 (P-trend = 0.001 and 0.0004, respectively). CoV+ patients were significantly older (7.5 vs. 2.5 yr) and mainly non-Caucasian (64 vs. 29%), had incomplete KD presentation (73 vs. 32%), lower leucocyte (9.5 vs. 15.5 × 109) and platelet count (174 vs. 423 × 109/L), higher inflammatory markers (C-Reactive Protein 18.5vs. 10.9 mg/dl) and terminal segment of the natriuretic atrial peptide (4,766 vs. 505 pg/ml), less aneurysm development (3.8 vs. 11.1%), and more myocardial dysfunction (30.8 vs. 1.6%) than PreCoV patients. Respiratory symptoms were not increased during the COVID-19 period. Conclusion: The KD CoV+ patients mostly meet pediatric inflammatory multisystem syndrome temporally associated with COVID-19/multisystem inflammatory syndrome in children criteria. Whether this is a novel entity or the same disease on different ends of the spectrum is yet to be clarified.
PB Frontiers Research Foundation
SN 2296-2360
YR 2021
FD 2021-01-18
LK http://hdl.handle.net/10668/17099
UL http://hdl.handle.net/10668/17099
LA en
NO Fernández-Cooke E, Grasa CD, Domínguez-Rodríguez S, Barrios Tascón A, Sánchez-Manubens J, Anton J, et al. Prevalence and Clinical Characteristics of SARS-CoV-2 Confirmed and Negative Kawasaki Disease Patients During the Pandemic in Spain. Front Pediatr. 2021 Jan 18;8:617039
NO CG is funded by the Spanish Ministry of Science and Innovation—Instituto de Salud Carlos III and Fondos FEDER (Contrato Río Hortega CM19/00015).
DS RISalud
RD Apr 6, 2025