RT Journal Article
T1 Alcoholic fermentation with Pichia kluyveri could improve the melatonin bioavailability of orange juice
A1 Cruz-Chamorro, Ivan
A1 Santos-Sanchez, Guillermo
A1 Alvarez-Sanchez, Nuria
A1 Martin-Prada, Laura
A1 Cerrillo, Isabel
A1 Ortega, Maria-Angeles
A1 Escudero-Lopez, Blanca
A1 Martin, Franz
A1 Alvarez-Rios, Ana Isabel
A1 Carrillo-Vico, Antonio
A1 Fernandez-Pachon, Maria-Soledad
K1 Melatonin
K1 6-sulfatoxymelatonin
K1 Orange juice
K1 Fermentation
K1 Antioxidant activity
K1 Total antioxidant capacity
K1 Oxidative stress
K1 Cardiovascular-diseases
K1 6-sulfatoxymelatonin
K1 Consumption
K1 Serotonin
K1 Oxygen
K1 Molecule
K1 Plasma
K1 Urine
AB Fermentation of orange juice (OJ) by Pichia kluyveri enhances the content of melatonin, a molecule with potent antioxidant effect. This study explores the levels of urine 6-sulfatoxymelatonin (6-SMT) in healthy subjects after fermented orange juice (FOJ) intake, and their association with antioxidant activity status. Nine participants ingested 500 mL of FOJ and their urine was collected at baseline and after 2, 5, 10, 15 and 24 h. After a two-week washout period, the intervention was repeated with OJ. 6-SMT levels were quantified by ELISA and antioxidant activity by TAC, FRAP and ORAC assays. A significant increase in both 6-SMT levels and antioxidant activity in urine was observed after FOJ ingestion compared to OJ. A positive correlation between TAC and 6-SMT levels was observed only after FOJ intake. This study shows for the first time that fermentation process increases melatonin bioavailability of OJ associated with an enhancement in antioxidant status.
PB Elsevier
SN 1756-4646
YR 2022
FD 2022-11-09
LK http://hdl.handle.net/10668/22304
UL http://hdl.handle.net/10668/22304
LA en
NO Ivan Cruz-Chamorro, Guillermo Santos-Sánchez, Nuria Álvarez-Sánchez, Laura Martín-Prada, Isabel Cerrillo, María-Ángeles Ortega, et al. Alcoholic fermentation with Pichia kluyveri could improve the melatonin bioavailability of orange juice, Journal of Functional Foods, 2022;(99),8,
DS RISalud
RD Apr 9, 2025