%0 Journal Article
%A Mohammadi, Mahmoud
%A IJzerman, Nikki S
%A Hohenberger, Peter
%A Rutkowski, Piotr
%A Jones, Robin L
%A Martin-Broto, Javier
%A Gronchi, Alessandro
%A Schöffski, Patrick
%A Vassos, Nikolaos
%A Farag, Sheima
%A Baia, Marco
%A Oosten, Astrid W
%A Steeghs, Neeltje
%A Desar, Ingrid M E
%A Reyners, An K L
%A van Sandick, J W
%A Bastiaannet, Esther
%A Gelderblom, Hans
%A Schrage, Yvonne
%T Clinicopathological features and treatment outcome of oesophageal gastrointestinal stromal tumour (GIST): A large, retrospective multicenter European study.
%D 2021
%U https://hdl.handle.net/10668/27243
%X Oesophageal gastrointestinal stromal tumours (GISTs) account for ≤1% of all GISTs. Consequently, evidence to guide clinical decision-making is limited. Clinicopathological features and outcomes in patients with primary oesophageal GIST from seven European countries were collected retrospectively. Eighty-three patients were identified, and median follow up was 55.0 months. At diagnosis, 59.0% had localized disease, 25.3% locally advanced and 13.3% synchronous metastasis. A biopsy (Fine Needle aspiration n = 29, histological biopsy n = 31) was performed in 60 (72.3%) patients. The mitotic count was low (5/5hpf) mitotic count were associated with worse disease free survival. Based on the current study, enucleation can be recommended for oesophageal GIST smaller than 4 cm, while oesophagectomy should be preserved for larger tumours. Patients with larger tumours (>4 cm) and/or high mitotic count should be treated with adjuvant therapy.
%K Gastrointestinal stromal tumours
%K Oesophagus
%K Surgery
%K Survival
%K Treatment outcome
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