RT Journal Article T1 SEOM-GEMCAD-TTD clinical guidelines for localized rectal cancer (2021). A1 Capdevila, Jaume A1 Gomez, Ma Auxiliadora A1 Guillot, Monica A1 Paez, David A1 Pericay, Carles A1 Safont, Maria Jose A1 Tarazona, Noelia A1 Vera, Ruth A1 Vidal, Joana A1 Sastre, Javier K1 Guideline K1 Rectal cancer K1 Total neoadjuvant therapy AB The management of localized rectal cancer requires a multidisciplinary approach to optimize outcomes, reduce morbidity and prevent under or overtreatments. While early stages may obtain benefit of local resections without any additional therapies, locally advanced rectal cancer becomes a challenge defining the better sequential strategy of surgery, radiotherapy and chemotherapy. The latest results of international phase III studies have positioned the total neoadjuvant therapy as a potential new standard of care in high risk rectal cancers, however, the best schedule is still not well defined. PB Springer YR 2022 FD 2022-02-22 LK http://hdl.handle.net/10668/21130 UL http://hdl.handle.net/10668/21130 LA en NO Capdevila J, Gómez MA, Guillot M, Páez D, Pericay C, Safont MJ, et al. SEOM-GEMCAD-TTD clinical guidelines for localized rectal cancer (2021). Clin Transl Oncol. 2022 Apr;24(4):646-657. doi: 10.1007/s12094-022-02816-9. Epub 2022 Mar 18. Erratum in: Clin Transl Oncol. 2022 Jul;24(7):1443-1444 DS RISalud RD Apr 11, 2025