RT Journal Article
T1 Survival, classifications, and desmosomal plaque genes in non-small cell lung cancer.
A1 Boyero, Laura
A1 Sánchez-Palencia, Abel
A1 Miranda-León, Ma Teresa
A1 Hernández-Escobar, Fernando
A1 Gómez-Capilla, Jose Antonio
A1 Fárez-Vidal, Ma Esther
K1 Survival
K1 adenocarcinoma
K1 squamous cell-carcinoma
K1 non-small cell lung cancer
K1 desmosomal plaque
K1 Estadificación de Neoplasias
K1 Análisis de Supervivencia
K1 Neoplasias Pulmonares
K1 Marcadores Biológicos
K1 Desmosomas
K1 Adenocarcinoma
K1 Carcinoma de Células Escamosas
K1 Carcinoma de Pulmón de Células no Pequeñas
AB Novel biomarkers are required to improve prognostic predictions obtained with lung cancer staging systems. This study of 62 surgically-treated Non-Small Cell Lung Cancer (NSCLC) patients had two objectives: i) to compare the predictive value of T-stage classifications between the 6(th) and 7(th) editions of the Tumor, Node, and Metastasis staging system (TNM); and ii) to examine the association of Pkp1 and/or Krt15 gene expression with survival and outcomes. Multivariate and Kaplan-Meier survival analyses were performed, examining the relationship of survival with T-stage, recurrence, and TNM-stage (by each TNM edition) and with the single/combined expression of Pkp1 and/or Krt15 genes. Five-year survival rates only significantly differed as a function of T-stage in patients without recurrence when estimated using the 6(th) edition of the TNM classification and only in patients in pathologic TNM-stage IA using the 7(th). Overall survival for patients with elevated expression of both genes was 13.5 months in those with adenocarcinoma and 34.6 months in those with squamous cell carcinoma. Overall survival was 30.4 months in patients with Pkp1 gene upregulation and 30.9 months in those with Krt15 gene upregulation. In conclusion, survival estimations as a function of T-staging differed between the 6(th) and 7(th) editions of TNM. Overall survival differed according to the expression of Pkp1 and/or Krt15 genes, although this relationship did not reach statistical significance.
PB Ivyspring International Publisher
YR 2013
FD 2013-07-10
LK http://hdl.handle.net/10668/1329
UL http://hdl.handle.net/10668/1329
LA en
NO Boyero L, Sánchez-Palencia A, Miranda-León MT, Hernández-Escobar F, Gómez-Capilla JA, Fárez-Vidal ME. Survival, classifications, and desmosomal plaque genes in non-small cell lung cancer. Int J Med Sci. 2013; 10(9):1166-73
NO Journal Article; Research Support, Non-U.S. Gov't;
DS RISalud
RD Apr 9, 2025