RT Journal Article
T1 Exosomes: Their Role in Pathogenesis, Diagnosis and Treatment of Diseases.
A1 Aheget, Houssam
A1 Mazini, Loubna
A1 Martin, Francisco
A1 Belqat, Boutaïna
A1 Marchal, Juan Antonio
A1 Benabdellah, Karim
K1 cancer pathogenesis
K1 diagnostics
K1 exosomes
K1 molecular composition
K1 therapeutics
AB Exosomes are lipid bilayer particles released from cells into their surrounding environment. These vesicles are mediators of near and long-distance intercellular communication and affect various aspects of cell biology. In addition to their biological function, they play an increasingly important role both in diagnosis and as therapeutic agents. In this paper, we review recent literature related to the molecular composition of exosomes, paying special attention to their role in pathogenesis, along with their application as biomarkers and as therapeutic tools. In this context, we analyze the potential use of exosomes in biomedicine, as well as the limitations that preclude their wider application.
PB MDPI AG
SN 2072-6694
YR 2020
FD 2020-12-24
LK http://hdl.handle.net/10668/16914
UL http://hdl.handle.net/10668/16914
LA en
NO Aheget H, Mazini L, Martin F, Belqat B, Marchal JA, Benabdellah K. Exosomes: Their Role in Pathogenesis, Diagnosis and Treatment of Diseases. Cancers (Basel). 2020 Dec 30;13(1):84.
NO This study was funded by the Spanish ISCIII Health Research Fund and the EuropeanRegional Development Fund (FEDER) through research grants PI12/01097, PI15/02015, PI18/00337(F.M.), PIE16-00045 (J.A.M.), DTS19/00145 (J.A.M.) and PI18/00330 (K.B.). The study was alsosupported by the Ministry of Science, Innovation and Universities (MICIU, RTI2018-101309-B-C22,FEDER funds), by the Consejería de Economía, Conocimiento, Empresas y Universidad de la Juntade Andalucía (SOMM17/6109/UGR, FEDER Funds), the Chair of “Doctors Galera-Requena in cancerstem cell research” (CMC-CTS963) and the Junta de Andalucia Health and Families Department(CARTPI-0001-201). The CECEyU and CSyF of the Junta de Andalucía FEDER/European CohesionFund (FSE) provided the following research grants: 2016000073391-TRA, 2016000073332-TRA, PI57069 and PAIDI-Bio326 (F.M.) and PI-0014-2016 (K.B.). K.B. was also on a Nicolas Monardes RegionalMinistry of Health contract (0006/2018). H.A. held a Research Excellence PhD Fellowship (2UAE2020)from the National Center for Scientific and Technical Research (CNRST). L.M. was supported by theMohammed VI Polytechnic University of Morocco
DS RISalud
RD Apr 6, 2025