RT Journal Article
T1 Detection of interleukin-2 is not useful for distinguishing between latent and active tuberculosis in clinical practice: a prospective cohort study
A1 Santin, M.
A1 Morandeira-Rego, F.
A1 Alcaide, F.
A1 Rabunal, R.
A1 Anibarro, L.
A1 Aguero-Balbin, R.
A1 Casas-Garcia, X.
A1 Perez-Escolano, E.
A1 Navarro, M. D.
A1 Sanchez, F.
A1 Coira-Nieto, A.
A1 Trigo-Daporta, M.
A1 Martinez-Menaca, A.
A1 Gonzalez-Cuevas, A.
A1 Lopez-Prieto, M. D.
A1 Dominguez-Castellano, A.
A1 Jove, N.
A1 IL-2 Study Team, 
K1 Active tuberculosis
K1 Interferon-gamma
K1 Interleukin-2
K1 Latent tuberculosis infection
K1 QuantiFERON
K1 Memory
K1 Cells
AB Objective: Previous reports have identified interleukin-2 (IL-2), quantified in the supernatants of QuantiFERON (R)-TB Gold In-tube (QFT) after 72 h of incubation, as a potential biomarker for distinguishing between latent and active tuberculosis (TB). However, its validity has not been tested in an appropriate clinical cohort.Methods: A multicentre study of 161 consecutive adult patients undergoing evaluation for active TB at eight TB Units in Spain. Interferon-gamma (IFN-gamma) and IL-2 were assessed in the supernatant of QFT after 16 -24 h and 72 h of incubation. The accuracy of IL-2 for indicating latent TB infection (LTBI) was assessed by receiving operating characteristic curves..Results: Twenty-eight participants were not infected, 43 had LTBI, 69 had TB, and 21 were not classifiable. Median (interquartile range) IL-2 concentrations after 72 h of incubation were 0.0 pg/mL (0.0-0.0) in uninfected individuals, 261.0 pg/mL (81.0-853.0) in LTBI individuals, 166.5 pg/mL (33.5-551.5) in patients with extrapulmonary TB, 95.0 pg/mL (26.0-283.0) in patients with smear-negative pulmonary TB, and 38.5 pg/mL (7.5-178.0) in patients with smear-positive pulmonary TB (p
PB Elsevier sci ltd
SN 1198-743X
YR 2016
FD 2016-12-01
LK http://hdl.handle.net/10668/18751
UL http://hdl.handle.net/10668/18751
LA en
DS RISalud
RD Apr 11, 2025