%0 Journal Article
%A Santin, M.
%A Morandeira-Rego, F.
%A Alcaide, F.
%A Rabunal, R.
%A Anibarro, L.
%A Aguero-Balbin, R.
%A Casas-Garcia, X.
%A Perez-Escolano, E.
%A Navarro, M. D.
%A Sanchez, F.
%A Coira-Nieto, A.
%A Trigo-Daporta, M.
%A Martinez-Menaca, A.
%A Gonzalez-Cuevas, A.
%A Lopez-Prieto, M. D.
%A Dominguez-Castellano, A.
%A Jove, N.
%A IL-2 Study Team
%T Detection of interleukin-2 is not useful for distinguishing between latent and active tuberculosis in clinical practice: a prospective cohort study
%D 2016
%@ 1198-743X
%U http://hdl.handle.net/10668/18751
%X Objective: Previous reports have identified interleukin-2 (IL-2), quantified in the supernatants of QuantiFERON (R)-TB Gold In-tube (QFT) after 72 h of incubation, as a potential biomarker for distinguishing between latent and active tuberculosis (TB). However, its validity has not been tested in an appropriate clinical cohort.Methods: A multicentre study of 161 consecutive adult patients undergoing evaluation for active TB at eight TB Units in Spain. Interferon-gamma (IFN-gamma) and IL-2 were assessed in the supernatant of QFT after 16 -24 h and 72 h of incubation. The accuracy of IL-2 for indicating latent TB infection (LTBI) was assessed by receiving operating characteristic curves..Results: Twenty-eight participants were not infected, 43 had LTBI, 69 had TB, and 21 were not classifiable. Median (interquartile range) IL-2 concentrations after 72 h of incubation were 0.0 pg/mL (0.0-0.0) in uninfected individuals, 261.0 pg/mL (81.0-853.0) in LTBI individuals, 166.5 pg/mL (33.5-551.5) in patients with extrapulmonary TB, 95.0 pg/mL (26.0-283.0) in patients with smear-negative pulmonary TB, and 38.5 pg/mL (7.5-178.0) in patients with smear-positive pulmonary TB (p
%K Active tuberculosis
%K Interferon-gamma
%K Interleukin-2
%K Latent tuberculosis infection
%K QuantiFERON
%K Memory
%K Cells
%~