RT Journal Article
T1 Aromatic DNA adducts and breast cancer risk: a case-cohort study within the EPIC-Spain.
A1 Agudo, Antonio
A1 Peluso, Marco
A1 Munnia, Armelle
A1 Luján-Barroso, Leila
A1 Barricarte, Aurelio
A1 Amiano, Pilar
A1 Navarro, Carmen
A1 Sanchez-Perez, Maria-Jose
A1 Quirós, J Ramón
A1 Ardanaz, Eva
A1 Larrañaga, Nerea
A1 Tormo, María-José
A1 Chirlaque, María-Dolores
A1 Rodríguez-Barranco, Miguel
A1 Sánchez-Cantalejo, Emilio
A1 Cellai, Filippo
A1 Bonet, Catalina
A1 Sala, Núria
A1 González, Carlos A
K1 Breast Cancer
K1 Polycyclic Aromatic Hydrocarbons
K1 DNA Adducts
K1 EPIC-Spain Cohort
K1 Tobacco Smoking
AB Epidemiologic evidence linking environmental exposure to polycyclic aromatic hydrocarbons (PAH) with breast cancer is limited. Measurement of DNA adducts formed by aromatic compounds, including PAH, has been carried in breast tissue samples and white blood cells from women with breast cancer and different kinds of controls. However, these studies provide inconsistent results and bias cannot be ruled out. During the 7-year follow-up period, 305 women were diagnosed with first primary breast cancer in the EPIC-Spain cohort, and were compared with a sample of 149 women without breast cancer at recruitment, using a case-cohort approach. Aromatic adducts to DNA from leukocytes collected at recruitment were measured by means of the 32P-post-labelling technique. The relative risk and 95% confidence interval (CI), adjusted by relevant confounders, were estimated by a modified version of Cox proportional hazards model. There was a significant increased risk for developing breast cancer when DNA adduct concentrations were doubled, with adjusted RR of 1.61 (95% CI 1.29-2.01). The increase in breast cancer risk was observed both for pre- and post-menopausal women. There was a significant interaction with tobacco smoking and body mass index, with higher effect of DNA adducts on breast cancer risk among smokers and women with normal weight. The results from our study support the hypothesis that factors leading to higher levels of aromatic DNA adducts in white blood cells may be involved in development of breast cancer.
PB Oxford Academic
YR 2017
FD 2017
LK http://hdl.handle.net/10668/11223
UL http://hdl.handle.net/10668/11223
LA en
NO Agudo A, Peluso M, Munnia A, Luján-Barroso L, Barricarte A, Amiano P, et al. Aromatic DNA adducts and breast cancer risk: a case-cohort study within the EPIC-Spain. Carcinogenesis. 2017 Jul 1;38(7):691-698.
DS RISalud
RD Apr 6, 2025