RT Journal Article
T1 High Plasma Glutamate and a Low Glutamine-to-Glutamate Ratio Are Associated with Increased Risk of Heart Failure but Not Atrial Fibrillation in the Prevención con Dieta Mediterránea (PREDIMED) Study.
A1 Papandreou, Christopher
A1 Hernández-Alonso, Pablo
A1 Bulló, Mònica
A1 Ruiz-Canela, Miguel
A1 Li, Jun
A1 Guasch-Ferré, Marta
A1 Toledo, Estefanía
A1 Clish, Clary
A1 Corella, Dolores
A1 Estruch, Ramon
A1 Cofán, Montserrat
A1 Fitó, Montserrat
A1 Razquin, Cristina
A1 Arós, Fernando
A1 Fiol, Miquel
A1 Santos-Lozano, José M
A1 Serra-Majem, Lluís
A1 Liang, Liming
A1 Martínez-González, Miguel A
A1 Hu, Frank B
A1 Salas-Salvadó, Jordi
K1 PREDIMED
K1 atrial fibrillation
K1 glutamate
K1 glutamine
K1 heart failure
AB Although the association between glutamate and glutamine in relation to cardiometabolic disorders has been evaluated, the role of these metabolites in the development of atrial fibrillation (AF) and heart failure (HF) remains unknown. We examined associations of glutamate, glutamine, and the glutamine-to-glutamate ratio with AF and HF incidence in a Mediterranean population at high cardiovascular disease (CVD) risk. The present study used 2 nested case-control studies within the PREDIMED (Prevención con Dieta Mediterránea) study. During ∼10 y of follow-up, there were 509 AF incident cases matched to 618 controls and 326 HF incident cases matched to 426 controls. Plasma concentrations of glutamate and glutamine were semiquantitatively profiled with LC-tandem MS. ORs were estimated with multivariable conditional logistic regression models. In fully adjusted models, per 1-SD increment, glutamate was associated with a 29% (95% CI: 1.08, 1.54) increased risk of HF and glutamine-to-glutamate ratio with a 20% (95% CI: 0.67, 0.94) decreased risk. Glutamine-to-glutamate ratio was also inversely associated with HF risk (OR per 1-SD increment: 0.80; 95% CI: 0.67, 0.94) when comparing extreme quartiles. Higher glutamate concentrations were associated with a worse cardiometabolic risk profile, whereas a higher glutamine-to-glutamate ratio was associated with a better cardiometabolic risk profile. No associations between the concentrations of these metabolites and AF were observed. Our findings suggest that high plasma glutamate concentrations possibly resulting from alterations in the glutamate-glutamine cycle may contribute to the development of HF in Mediterranean individuals at high CVD risk.This trial was registered at www.isrctn.com as ISRCTN35739639.
YR 2020
FD 2020
LK http://hdl.handle.net/10668/16265
UL http://hdl.handle.net/10668/16265
LA en
DS RISalud
RD Apr 6, 2025