RT Journal Article
T1 Role of Exocrine and Endocrine Insufficiency in the Management of Patients with Chronic Pancreatitis.
A1 Diéguez-Castillo, Carmelo
A1 Jiménez-Luna, Cristina
A1 Martín-Ruiz, Jose Luis
A1 Martínez-Galán, Joaquina
A1 Prados, José
A1 Torres, Carolina
A1 González-Ramírez, Amanda Rocío
A1 Caba, Octavio
K1 chronic pancreatitis
K1 diabetes mellitus
K1 exocrine pancreatic insufficiency
K1 nutritional status
K1 pancreatic complications.
AB Exocrine pancreatic insufficiency results from the destruction of the pancreatic parenchyma and is diagnosed by using direct or indirect tests, both of which have shortcomings. Chronic pancreatitis is the most frequent cause of this pathology in adults. Patients meeting radiological or histological diagnostic criteria of chronic pancreatitis are enrolled and the stool elastase test is conducted, considering fecal elastase levels >200 µg/g to represent normal pancreatic function, and levels 200 µg/g to represent normal pancreatic function, and levels  Exocrine pancreatic insufficiency is detected in 60% of the patients. Among these, 83.3% are severe cases, and 72% of the latter also are diagnosed with endocrine pancreatic insufficiency (diabetes mellitus). During the nutritional status study, HbA1c levels are significantly higher, and magnesium and prealbumin levels are significantly lower in patients with exocrine pancreatic insufficiency than in those without this disease. Exocrine and endocrine pancreatic insufficiency are highly prevalent among patients with chronic pancreatitis and an early diagnosis of these diseases is vital to improve the clinical management of these patients and reduce their risk of mortality.
SN 2077-0383
YR 2020
FD 2020-06-26
LK https://hdl.handle.net/10668/26129
UL https://hdl.handle.net/10668/26129
LA en
DS RISalud
RD Apr 17, 2025