TY - GEN AU - Borroto-Escuela, Dasiel O. AU - Wydra, Karolina AU - Pintsuk, Julia AU - Narvaez, Manuel AU - Corrales, Fidel AU - Zaniewska, Magdalena AU - Agnati, Luigi F. AU - Franco, Rafael AU - Tanganelli, Sergio AU - Ferraro, Luca AU - Filip, Malgorzata AU - Fuxe, Kjell PY - 2016 DO - https://doi.org/10.1155/2016/4827268 SN - 2090-5904 UR - http://hdl.handle.net/10668/19046 T2 - Neural plasticity AB - Our hypothesis is that allosteric receptor-receptor interactions in homo-and heteroreceptor complexes may form the molecular basis of learning and memory. This principle is illustrated by showing how cocaine abuse can alter the adenosine A2AR-dopamine... LA - en PB - Hindawi ltd KW - Adenosine a(2a) receptors KW - Proximity ligation assay KW - Higher-order oligomers KW - Synaptic-transmission KW - Integrative mechanism KW - D2 receptors KW - Dopamine KW - Modulation KW - Glutamate KW - Communication KW - Cocaine-Related Disorders KW - Dopamine KW - Protein Subunits KW - Adenosine KW - Motivation KW - Cocaine KW - Basal Ganglia TI - Understanding the Functional Plasticity in Neural Networks of the Basal Ganglia in Cocaine Use Disorder: A Role for Allosteric Receptor-Receptor Interactions in A2A-D2 Heteroreceptor Complexes TY - review VL - 2016 ER -