RT Journal Article
T1 Blood Metabolic Signatures of Body Mass Index: A Targeted Metabolomics Study in the EPIC Cohort.
A1 Carayol, Marion
A1 Leitzmann, Michael F
A1 Ferrari, Pietro
A1 Zamora-Ros, Raul
A1 Achaintre, David
A1 Stepien, Magdalena
A1 Schmidt, Julie A
A1 Travis, Ruth C
A1 Overvad, Kim
A1 Tjønneland, Anne
A1 Hansen, Louise
A1 Kaaks, Rudolf
A1 Kühn, Tilman
A1 Boeing, Heiner
A1 Bachlechner, Ursula
A1 Trichopoulou, Antonia
A1 Bamia, Christina
A1 Palli, Domenico
A1 Agnoli, Claudia
A1 Tumino, Rosario
A1 Vineis, Paolo
A1 Panico, Salvatore
A1 Quirós, J Ramón
A1 Sánchez-Cantalejo, Emilio
A1 Huerta, José María
A1 Ardanaz, Eva
A1 Arriola, Larraitz
A1 Agudo, Antonio
A1 Nilsson, Jan
A1 Melander, Olle
A1 Bueno-de-Mesquita, Bas
A1 Peeters, Petra H
A1 Wareham, Nick
A1 Khaw, Kay-Tee
A1 Jenab, Mazda
A1 Key, Timothy J
A1 Scalbert, Augustin
A1 Rinaldi, Sabina
K1 blood
K1 body mass index
K1 metabolic profiling
K1 obesity
K1 targeted metabolome
AB Metabolomics is now widely used to characterize metabolic phenotypes associated with lifestyle risk factors such as obesity. The objective of the present study was to explore the associations of body mass index (BMI) with 145 metabolites measured in blood samples in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Metabolites were measured in blood from 392 men from the Oxford (UK) cohort (EPIC-Oxford) and in 327 control subjects who were part of a nested case-control study on hepatobiliary carcinomas (EPIC-Hepatobiliary). Measured metabolites included amino acids, acylcarnitines, hexoses, biogenic amines, phosphatidylcholines, and sphingomyelins. Linear regression models controlled for potential confounders and multiple testing were run to evaluate the associations of metabolite concentrations with BMI. 40 and 45 individual metabolites showed significant differences according to BMI variations, in the EPIC-Oxford and EPIC-Hepatobiliary subcohorts, respectively. Twenty two individual metabolites (kynurenine, one sphingomyelin, glutamate and 19 phosphatidylcholines) were associated with BMI in both subcohorts. The present findings provide additional knowledge on blood metabolic signatures of BMI in European adults, which may help identify mechanisms mediating the relationship of BMI with obesity-related diseases.
PB American Chemical Society
YR 2017
FD 2017-08-11
LK http://hdl.handle.net/10668/11455
UL http://hdl.handle.net/10668/11455
LA en
NO Carayol M, Leitzmann MF, Ferrari P, Zamora-Ros R, Achaintre D, Stepien M, et al. Blood Metabolic Signatures of Body Mass Index: A Targeted Metabolomics Study in the EPIC Cohort. J Proteome Res. 2017 Sep 1;16(9):3137-3146.
DS RISalud
RD Apr 18, 2025