RT Journal Article
T1 Evolution of Metabolic Phenotypes of Obesity in Coronary Patients after 5 Years of Dietary Intervention: From the CORDIOPREV Study
A1 Martin-Piedra, Laura
A1 Alcala-Diaz, Juan F.
A1 Gutierrez-Mariscal, Francisco M.
A1 Arenas de Larriva, Antonio P.
A1 Romero-Cabrera, Juan L.
A1 Torres-Peña, Jose D.
A1 Caballero-Villarraso, Javier
A1 Luque, Raul M.
A1 Perez-Martinez, Pablo
A1 Lopez-Miranda, Jose
A1 Delgado-Lista, Javier
K1 Obesity metabolic phenotypes
K1 Metabolically healthy obese
K1 Metabolically unhealthy obese
K1 Fatty liver index
K1 Diet intervention
K1 Mediterranean diet
K1 Low-fat diet
K1 Coronary patients
K1 Phenotype
K1 Obesidad
K1 Obesidad metabólica benigna
K1 Hígado graso
K1 Dieta
K1 Dieta mediterránea
K1 Dieta con restricción de grasas
K1 Enfermedad coronaria
K1 Fenotipo
AB Background: Obesity phenotypes with different metabolic status have been described previously. We analyzed metabolic phenotypes in obese coronary patients during a 5-year follow-up, and examined the factors influencing this evolution. Methods: The CORDIOPREV study is a randomized, long-term secondary prevention study with two healthy diets: Mediterranean and low-fat. All obese patients were classified as either metabolically healthy obese (MHO) or metabolically unhealthy obese (MUO). We evaluated the changes in the metabolic phenotypes and related variables after 5 years of dietary intervention. Results: Initially, 562 out of the 1002 CORDIOPREV patients were obese. After 5 years, 476 obese patients maintained their clinical and dietary visits; 71.8% of MHO patients changed to unhealthy phenotypes (MHO-Progressors), whereas the MHO patients who maintained healthy phenotypes (MHO-Non-Progressors) lost more in terms of their body mass index (BMI) and had a lower fatty liver index (FLI-score) (p < 0.05). Most of the MUO (92%) patients maintained unhealthy phenotypes (MUO-Non-Responders), but 8% became metabolically healthy (MUO-Responders) after a significant decrease in their BMI and FLI-score, with improvement in all metabolic criteria. No differences were found among dietary groups. Conclusions: A greater loss of weight and liver fat is associated with a lower progression of the MHO phenotype to unhealthy phenotypes. Likewise, a marked improvement in these parameters is associated with regression from MUO to healthy phenotypes.
PB MDPI
YR 2021
FD 2021-11-12
LK http://hdl.handle.net/10668/4459
UL http://hdl.handle.net/10668/4459
LA en
NO Martin-Piedra L, Alcala-Diaz JF, Gutierrez-Mariscal FM, Arenas de Larriva AP, Romero-Cabrera JL, Torres-Peña JD, et al. Evolution of Metabolic Phenotypes of Obesity in Coronary Patients after 5 Years of Dietary Intervention: From the CORDIOPREV Study. Nutrients. 2021 Nov 12;13(11):4046
DS RISalud
RD Apr 6, 2025