RT Journal Article
T1 Evolution of Metabolic Phenotypes of Obesity in Coronary Patients after 5 Years of Dietary Intervention: From the CORDIOPREV Study
A1 Martin-Piedra, Laura
A1 Alcala-Diaz, Juan F.
A1 Gutierrez-Mariscal, Francisco M.
A1 Arenas de Larriva, Antonio P.
A1 Romero-Cabrera, Juan L.
A1 Torres-Peña, Jose D.
A1 Caballero-Villarraso, Javier
A1 Luque, Raul M.
A1 Perez-Martinez, Pablo
A1 Lopez-Miranda, Jose
A1 Delgado-Lista, Javier
K1 Obesity metabolic phenotypes
K1 Metabolically healthy obese
K1 Metabolically unhealthy obese
K1 Fatty liver index
K1 Diet intervention
K1 Mediterranean diet
K1 Low-fat diet
K1 Coronary patients
K1 Phenotype
AB Background: Obesity phenotypes with different metabolic status have been described previously. We analyzed metabolic phenotypes in obese coronary patients during a 5-year follow-up, and examined the factors influencing this evolution. Methods: The CORDIOPREV study is a randomized, long-term secondary prevention study with two healthy diets: Mediterranean and low-fat. All obese patients were classified as either metabolically healthy obese (MHO) or metabolically unhealthy obese (MUO). We evaluated the changes in the metabolic phenotypes and related variables after 5 years of dietary intervention. Results: Initially, 562 out of the 1002 CORDIOPREV patients were obese. After 5 years, 476 obese patients maintained their clinical and dietary visits; 71.8% of MHO patients changed to unhealthy phenotypes (MHO-Progressors), whereas the MHO patients who maintained healthy phenotypes (MHO-Non-Progressors) lost more in terms of their body mass index (BMI) and had a lower fatty liver index (FLI-score) (p < 0.05). Most of the MUO (92%) patients maintained unhealthy phenotypes (MUO-Non-Responders), but 8% became metabolically healthy (MUO-Responders) after a significant decrease in their BMI and FLI-score, with improvement in all metabolic criteria. No differences were found among dietary groups. Conclusions: A greater loss of weight and liver fat is associated with a lower progression of the MHO phenotype to unhealthy phenotypes. Likewise, a marked improvement in these parameters is associated with regression from MUO to healthy phenotypes.
PB MDPI
YR 2021
FD 2021-11-12
LK http://hdl.handle.net/10668/4459
UL http://hdl.handle.net/10668/4459
LA en
NO Martin-Piedra L, Alcala-Diaz JF, Gutierrez-Mariscal FM, Arenas de Larriva AP, Romero-Cabrera JL, Torres-Peña JD, et al. Evolution of Metabolic Phenotypes of Obesity in Coronary Patients after 5 Years of Dietary Intervention: From the CORDIOPREV Study. Nutrients. 2021 Nov 12;13(11):4046
DS RISalud
RD Jul 31, 2025