%0 Journal Article
%A Martin-Piedra, Laura
%A Alcala-Diaz, Juan F.
%A Gutierrez-Mariscal, Francisco M.
%A Arenas de Larriva, Antonio P.
%A Romero-Cabrera, Juan L.
%A Torres-Peña, Jose D.
%A Caballero-Villarraso, Javier
%A Luque, Raul M.
%A Perez-Martinez, Pablo
%A Lopez-Miranda, Jose
%A Delgado-Lista, Javier
%T Evolution of Metabolic Phenotypes of Obesity in Coronary Patients after 5 Years of Dietary Intervention: From the CORDIOPREV Study
%D 2021
%U http://hdl.handle.net/10668/4459
%X Background: Obesity phenotypes with different metabolic status have been described previously. We analyzed metabolic phenotypes in obese coronary patients during a 5-year follow-up, and examined the factors influencing this evolution. Methods: The CORDIOPREV study is a randomized, long-term secondary prevention study with two healthy diets: Mediterranean and low-fat. All obese patients were classified as either metabolically healthy obese (MHO) or metabolically unhealthy obese (MUO). We evaluated the changes in the metabolic phenotypes and related variables after 5 years of dietary intervention. Results: Initially, 562 out of the 1002 CORDIOPREV patients were obese. After 5 years, 476 obese patients maintained their clinical and dietary visits; 71.8% of MHO patients changed to unhealthy phenotypes (MHO-Progressors), whereas the MHO patients who maintained healthy phenotypes (MHO-Non-Progressors) lost more in terms of their body mass index (BMI) and had a lower fatty liver index (FLI-score) (p < 0.05). Most of the MUO (92%) patients maintained unhealthy phenotypes (MUO-Non-Responders), but 8% became metabolically healthy (MUO-Responders) after a significant decrease in their BMI and FLI-score, with improvement in all metabolic criteria. No differences were found among dietary groups. Conclusions: A greater loss of weight and liver fat is associated with a lower progression of the MHO phenotype to unhealthy phenotypes. Likewise, a marked improvement in these parameters is associated with regression from MUO to healthy phenotypes.
%K Obesity metabolic phenotypes
%K Metabolically healthy obese
%K Metabolically unhealthy obese
%K Fatty liver index
%K Diet intervention
%K Mediterranean diet
%K Low-fat diet
%K Coronary patients
%K Phenotype
%K Obesidad
%K Obesidad metabólica benigna
%K Hígado graso
%K Dieta
%K Dieta mediterránea
%K Dieta con restricción de grasas
%K Enfermedad coronaria
%K Fenotipo
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