%0 Journal Article
%A Perez-Martinez, Pablo
%A Alcala-Diaz, Juan F
%A Kabagambe, Edmon K
%A Garcia-Rios, Antonio
%A Tsai, Michael Y
%A Delgado-Lista, Javier
%A Kolovou, Genovefa
%A Straka, Robert J
%A Gomez-Delgado, Francisco
%A Hopkins, Paul N
%A Marin, Carmen
%A Borecki, Ingrid
%A Yubero-Serrano, Elena M
%A Hixson, James E
%A Camargo, Antonio
%A Province, Michael A
%A Lopez-Moreno, Javier
%A Rodriguez-Cantalejo, Fernando
%A Tinahones, Francisco J
%A Mikhailidis, Dimitri P
%A Perez-Jimenez, Francisco
%A Arnett, Donna K
%A Ordovas, Jose M
%A Lopez-Miranda, Jose
%T Assessment of postprandial triglycerides in clinical practice: Validation in a general population and coronary heart disease patients.
%D 2016
%@ 1933-2874
%U http://hdl.handle.net/10668/10481
%X Previous studies have suggested that for clinical purposes, subjects with fasting triglycerides (TGs) between 89-180 mg/dl (1-2 mmol/l) would benefit from postprandial TGs testing. To determine the postprandial TG response in 2 independent studies and validate who should benefit diagnostically from an oral-fat tolerance test (OFTT) in clinical practice. A population of 1002 patients with coronary heart disease (CHD) from the CORDIOPREV clinical trial and 1115 white US subjects from the GOLDN study underwent OFTTs. Subjects were classified into 3 groups according to fasting cut points of TGs to predict the usefulness of OFTT: (1) TG  180 mg/dl (>2 mmol/l). Postprandial TG concentration at any point > 220 mg/dl (>2.5 mmol/l) has been pre-established as an undesirable postprandial response. Of the total, 49% patients with CHD and 42% from the general population showed an undesirable response after the OFTT. The prevalence of undesirable postprandial TG in the CORDIOPREV clinical trial was 12.8, 50.3, and 89.7%, in group 1, 2, and 3, respectively (P  These two studies validate the predictive values reported in a previous consensus. Moreover, the findings of the CORDIOPREV and GOLDN studies show that an OFTT is useful to identify postprandial hyperlipidemia in subjects with fasting TG between 1-2 mmol/l (89-180 mg/dL), because approximately half of them have hidden postprandial hyperlipidemia, which may influence treatment. An OFTT does not provide additional information regarding postprandial hyperlipidemia in subjects with low TG (2 mmol/l, >180 mg/dl).
%K CORDIOPREV study
%K Coronary heart disease
%K GOLDN study
%K Oral-fat tolerance test
%K Postprandial lipemia
%K Triglycerides
%~