RT Journal Article
T1 Diagnosis of latent tuberculosis in patients with systemic lupus erythematosus: T.SPOT.TB versus tuberculin skin test.
A1 Arenas Miras, Maria Del Mar
A1 Hidalgo-Tenorio, Carmen
A1 Jimenez-Gamiz, Pilar
A1 Jiménez-Alonso, Juan
K1 Estudios Transversales
K1 Femenino
K1 Humanos
K1 Tuberculosis Latente
K1 Masculino
K1 Mediana Edad
K1 Estudios Retrospectivos
K1 Prueba de Tuberculina
K1 Adulto
K1 Lupus eritematoso sistémico
AB Early studies in patients with systemic lupus erythematosus (SLE) reported increased incidence of tuberculosis. The tuberculin skin test (TST) is the technique of choice to detect latent tuberculosis infection (LTBI) but has several limitations.OBJECTIVESWe compared TST and the newer T.SPOT.TB test to diagnose LTBI in SLE patients.METHODSIn this observational cohort study conducted between August 2009 and February 2012, we recruited 92 patients from those attending the SLE clinic of our university hospital. Data recorded were epidemiological and sociodemographic characteristics. Laboratory analyses included TST and T.SPOT.TB tests.RESULTSOf the patients studied, 92% were women with an average age of 42.7 years. Overall, the degree of correlation between the two tests was low (Kappa index = 0.324) but was better in patients not receiving corticosteroids (CTC)/immunosuppressive (IS) therapy (Kappa = 0.436) and in those receiving hydroxychloroquine (Kappa = 0.473). While TST results were adversely affected by those receiving CTC and/or IS drugs (P = 0.021), the T.SPOT.TB results were not.CONCLUSIONAlthough the TST test remains a useful tool for diagnosing LTBI in SLE patients, the T.SPOT.TB test is perhaps better employed when the patient is receiving CTC and/or IS drugs.
PB Hindawi Publishing Corporation
YR 2014
FD 2014-05-28
LK http://hdl.handle.net/10668/1899
UL http://hdl.handle.net/10668/1899
LA en
NO Arenas Miras Mdel M, Hidalgo-Tenorio C, Jimenez-Gamiz P, Jiménez-Alonso J. Diagnosis of latent tuberculosis in patients with systemic lupus erythematosus: T.SPOT.TB versus tuberculin skin test. Biomed Res Int; 2014:291031
NO Clinical Trial; Comparative Study; Journal Article; Observational Study;
DS RISalud
RD Apr 7, 2025