RT Journal Article
T1 Consumption of Fish and Long-chain n-3 Polyunsaturated Fatty Acids Is Associated With Reduced Risk of Colorectal Cancer in a Large European Cohort.
A1 Aglago, Elom K
A1 Huybrechts, Inge
A1 Murphy, Neil
A1 Casagrande, Corinne
A1 Nicolas, Genevieve
A1 Pischon, Tobias
A1 Fedirko, Veronika
A1 Severi, Gianluca
A1 Boutron-Ruault, Marie-Christine
A1 Fournier, Agnès
A1 Katzke, Verena
A1 Kühn, Tilman
A1 Olsen, Anja
A1 Tjønneland, Anne
A1 Dahm, Christina C
A1 Overvad, Kim
A1 Lasheras, Cristina
A1 Agudo, Antonio
A1 Sanchez-Perez, Maria-Jose
A1 Amiano, Pilar
A1 Huerta, José Maria
A1 Ardanaz, Eva
A1 Perez-Cornago, Aurora
A1 Trichopoulou, Antonia
A1 Karakatsani, Anna
A1 Martimianaki, Georgia
A1 Palli, Domenico
A1 Pala, Valeria
A1 Tumino, Rosario
A1 Naccarati, Alessio
A1 Panico, Salvatore
A1 Bueno-de-Mesquita, Bas
A1 May, Anne
A1 Derksen, Jeroen W G
A1 Hellstrand, Sophie
A1 Ohlsson, Bodil
A1 Wennberg, Maria
A1 Van Guelpen, Bethany
A1 Skeie, Guri
A1 Brustad, Magritt
A1 Weiderpass, Elisabete
A1 Cross, Amanda J
A1 Ward, Heather
A1 Riboli, Elio
A1 Norat, Teresa
A1 Chajes, Veronique
A1 Gunter, Marc J
K1 Epidemiologic
K1 Omega 3
K1 Seafood
K1 Tumorigenesis
AB There is an unclear association between intake of fish and long-chain n-3 polyunsaturated fatty acids (n-3 LC-PUFAs) and colorectal cancer (CRC). We examined the association between fish consumption, dietary and circulating levels of n-3 LC-PUFAs, and ratio of n-6:n-3 LC-PUFA with CRC using data from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Dietary intake of fish (total, fatty/oily, lean/white) and n-3 LC-PUFA were estimated by food frequency questionnaires given to 521,324 participants in the EPIC study; among these, 6291 individuals developed CRC (median follow up, 14.9 years). Levels of phospholipid LC-PUFA were measured by gas chromatography in plasma samples from a sub-group of 461 CRC cases and 461 matched individuals without CRC (controls). Multivariable Cox proportional hazards and conditional logistic regression models were used to calculate hazard ratios (HRs) and odds ratios (ORs), respectively, with 95% CIs. Total intake of fish (HR for quintile 5 vs 1, 0.88; 95% CI, 0.80-0.96; Ptrend = .005), fatty fish (HR for quintile 5 vs 1, 0.90; 95% CI, 0.82-0.98; Ptrend = .009), and lean fish (HR for quintile 5 vs 1, 0.91; 95% CI, 0.83-1.00; Ptrend = .016) were inversely associated with CRC incidence. Intake of total n-3 LC-PUFA (HR for quintile 5 vs 1, 0.86; 95% CI, 0.78-0.95; Ptrend = .010) was also associated with reduced risk of CRC, whereas dietary ratio of n-6:n-3 LC-PUFA was associated with increased risk of CRC (HR for quintile 5 vs 1, 1.31; 95% CI, 1.18-1.45; Ptrend  In an analysis of dietary patterns of participants in the EPIC study, we found regular consumption of fish, at recommended levels, to be associated with a lower risk of CRC, possibly through exposure to n-3 LC-PUFA. Levels of n-3 LC-PUFA in plasma were not associated with CRC risk, but there may be differences in risk at different regions of the colon.
YR 2019
FD 2019-06-25
LK http://hdl.handle.net/10668/14194
UL http://hdl.handle.net/10668/14194
LA en
NO Aglago EK, Huybrechts I, Murphy N, Casagrande C, Nicolas G, Pischon T, et al. Consumption of Fish and Long-chain n-3 Polyunsaturated Fatty Acids Is Associated With Reduced Risk of Colorectal Cancer in a Large European Cohort. Clin Gastroenterol Hepatol. 2020 Mar;18(3):654-666.e6.
DS RISalud
RD Apr 6, 2025