RT Journal Article
T1 Total antioxidant capacity of plasma in asymptomatic carrier state of Neisseria meningitidis
A1 Uberos, J
A1 Molina-Carballo, A
A1 Galdo-Muñoz, G
A1 Muñoz-Hoyos, A
K1 Portador Sano
K1 Antioxidantes
K1 Preescolar
K1 Niño
K1 Humanos
K1 Infantil
K1 Recién nacido
K1 Infecciones Meningocócicas
K1 Nasofaringe
AB Reduction of the antioxidant capacity of plasma has been linked with the impairment of an effective immune response and so we hypothesized that the carriage rate of Neisseria meningitidis in asymptomatic subjects might correlate with the levels of antioxidants in plasma. To this end we took pharyngeal swabs from 339 children in Marquesado Basic Health Zone, Granada, Spain and in addition determined the total antioxidant capacity (TAC) in plasma samples from these subjects. The overall prevalence of N. meningitidis carriage was 5.9% (mean age 7.1 years) with rates of 10.3% in children aged 3 < or =years, 3.9% between 4 and 7 years and 2.4% in older subjects. Plasma TAC for the < or =3-year-olds was 0.13 for carriers and 1.10 for non-carrier controls (P=0.04), 0.13 for carriers aged 4-7 years (controls 0.63) and 0.28 for carriers aged >7 years (controls 0.52). We analysed the association between TAC in plasma (<0.37 - 2 S.D.) and the carrier state of N. meningitidis. In the carrier state, the odds ratio for this association (TAC in plasma <0.25) was 8.44 (95% CI 1.5-48.9). These findings may suggest a reduced immune response in the host favourable to nasopharyngeal persistence of meningococci.
PB Cambridge University Press
SN 0950-2688
YR 2007
FD 2007-07
LK http://hdl.handle.net/10668/551
UL http://hdl.handle.net/10668/551
LA en
NO Uberos J, Molina-Carballo A, Galdo-Muñoz G, Muñoz-Hoyos A. Total antioxidant capacity of plasma in asymptomatic carrier state of Neisseria meningitidis. Epidemiol. Infect.. 2007 Jul; 135(5):857-60
NO Journal Article;
DS RISalud
RD Apr 10, 2025