RT Journal Article
T1 Incidence of hypoxic-ischaemic encephalopathy and use of therapeutic hypothermia in Spain
A1 Arnaez, Juan
A1 Garcia-Alix, Alfredo
A1 Arca, Gemma
A1 Valverde, Eva
A1 Caserio, Sonia
A1 Teresa Moral, M.
A1 Benavente-Fernandez, Isabel
A1 Lubian-Lopez, Simon
A1 Diez-Delgado, J.
A1 Tofe, I.
A1 Jerez, A. E.
A1 Hurtado, J. A.
A1 Ceballos, J. M.
A1 Millan, M. L.
A1 Esquivel, M. D.
A1 Ruiz, C.
A1 Baca, M.
A1 Tapia, E.
A1 Losada, M.
A1 Torres, E.
A1 Pavon, A.
A1 Jimenez, P. J.
A1 Jimenez, F.
A1 Ventura, M. P.
A1 Rite, S.
A1 Gonzalez, T.
A1 Arias, R. P.
A1 Balliu, P. R.
A1 Lloreda-Garcia, J. M.
A1 Alcaraz, J. L.
A1 Tapia, C.
A1 de la Morena, A.
A1 Centelles, I.
A1 Guemes, I.
A1 Estan, J.
A1 Alberola, A.
A1 Aparici, S.
A1 Lopez, R.
A1 Beceiro, J.
A1 Garcia, B.
A1 Martinez, L.
A1 Gonzalez, E.
A1 Arruza, L.
A1 Blanco, M. D.
A1 Arias, B.
A1 Mar, F.
A1 Jimenez, J.
A1 Romera, G.
A1 Cunarro, A.
A1 Munoz, C.
A1 Cabanas, F.
A1 Montero, R.
A1 Tejedor, J. C.
A1 Santana, C.
A1 Reyes, B.
A1 Romero, S.
A1 Orizaola, A.
A1 Baquero, M.
A1 Hernandez, D.
A1 Pantoja, A.
A1 Vega, C.
A1 Castanon, L.
A1 Gutierrez, E. P.
A1 Benito, M.
A1 Garcia, M. J.
A1 Lopez-Vilchez, M. A.
A1 Castells, L.
A1 Domingo, M.
A1 Coroleu, W.
A1 Boix, H.
A1 Porta, R.
A1 Martinez-Nadal, S.
A1 Jimenez, E.
A1 Sole, E.
A1 Albujar, M.
A1 Fernandez, E. M.
A1 Barrio, A. R.
A1 Pinan, E.
A1 Avila-Alvarez, A.
A1 Vazquez, M. E.
A1 Balado, N.
A1 Crespo, P. A.
A1 Couce, M. L.
A1 Concheiro-Guisan, A.
A1 Esteban, I.
A1 Lavilla, A.
A1 Alzina, V.
A1 Aguirre, A.
A1 Loureiro, B.
A1 Echaniz, I.
A1 Elorza, M. D.
A1 Euba, A.
A1 Grp Trabajo EHI-ESP, 
K1 Hypoxia-ischaemia
K1 Asphyxia
K1 Newborn
K1 Incidence
K1 Induced hypothermia
K1 Spain
K1 Death
K1 Neonatal encephalopathy
K1 Perinatal asphyxia
K1 Experience
K1 Newborns
K1 Program
K1 Implementation
K1 Management
K1 Outcomes
AB Introduction: There are no data on the incidence of hypoxic-ischaemic encephalopathy (HIE) and the implementation of therapeutic hypothermia (TH) in Spain.Methods: This is a cross-sectional, national study, performed using an on-line questionnaire targeting level III neonatal care units in Spain. Participants were requested to provide data of all newborns = 35 weeks of gestational age diagnosed with moderate-severe HIE over a two year-period (2012-2013), and of the implementation of TH up to June 2015.Results: All (90) contacted hospitals participated. HIE incidence rate was 0.77/1000 live newborns (95% CI 0.72 - 0.83). During 2012-2013, 86% of the newborns diagnosed with moderate-severe HIE received TH (active or passive). Active TH was increasingly used, from 78% in 2012 to 85% in 2013 (P=.01). Of the 14% that did not receive TH, it was mainly due to a delay in the diagnosis or inter-hospital transfer, and to the fact that the treatment was not offered. More than half (57%) were born in hospitals where TH was not provided, and passive hypothermia was used for inter-hospital patient transfer, and in 39% of the cases by inappropriately trained personnel. By June 2015, 57 out of 90 centres had implemented TH, of which 54 performed whole-body TH (using servo-controlled devices). The geographical distribution of centres with active TH, and the number of newborn that received TH, was heterogeneous.Conclusions: The incidence of moderate-severe HIE is homogeneous across Spanish territory. Significant progress is being made in the implementation of TH, however it is necessary to increase the availability of active TH between Autonomous Communities, to improve early diagnosis, and to guarantee high quality patient transfer to referral centres. (C) 2017 Asociacion Espanola de Pediatria. Published by Elsevier Espana, S.L.U.
PB Ediciones doyma s a
SN 1695-4033
YR 2018
FD 2018-07-01
LK https://hdl.handle.net/10668/25184
UL https://hdl.handle.net/10668/25184
LA es
DS RISalud
RD Apr 8, 2025