RT Journal Article
T1 Evaluation of neurotrophic factors and education level as predictors of cognitive decline in alcohol use disorder
A1 Requena-Ocaña, Nerea
A1 Araos, Pedro
A1 Flores, María
A1 García-Marchena, Nuria
A1 Silva-Peña, Daniel
A1 Aranda, Jesús
A1 Rivera, Patricia
A1 Ruiz, Juan Jesús
A1 Serrano, Antonia
A1 Pavón, Francisco Javier
A1 Suárez, Juan
A1 Rodríguez de Fonseca, Fernando
K1 Neuroscience
K1 Psychology
K1 Biomarkers
K1 Neurociencias
K1 Psicología
K1 Biomarcadores
AB Cognitive reserve (CR) is the capability of an individual to cope with a brain pathology through compensatory mechanisms developed through cognitive stimulation by mental and physical activity. Recently, it has been suggested that CR has a protective role against the initiation of substance use, substance consumption patterns and cognitive decline and can improve responses to treatment. However, CR has never been linked to cognitive function and neurotrophic factors in the context of alcohol consumption. The present cross-sectional study aims to evaluate the association between CR (evaluated by educational level), cognitive impairment (assessed using a frontal and memory loss assessment battery) and circulating levels of brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) in patients with alcohol use disorder (AUD). Our results indicated that lower educational levels were accompanied by earlier onset of alcohol consumption and earlier development of alcohol dependence, as well as impaired frontal cognitive function. They also suggest that CR, NT-3 and BDNF may act as compensatory mechanisms for cognitive decline in the early stages of AUD, but not in later phases. These parameters allow the identification of patients with AUD who are at risk of cognitive deterioration and the implementation of personalized interventions to preserve cognitive function.
PB Springer Nature
YR 2021
FD 2021-08-02
LK http://hdl.handle.net/10668/3695
UL http://hdl.handle.net/10668/3695
LA en
NO Requena-Ocaña N, Araos P, Flores M, García-Marchena N, Silva-Peña D, Aranda J, et al. Evaluation of neurotrophic factors and education level as predictors of cognitive decline in alcohol use disorder. Sci Rep. 2021 Aug 2;11(1):15583
DS RISalud
RD Apr 5, 2025