RT Journal Article
T1 Association of Tryptophan Metabolites with Incident Type 2 Diabetes in the PREDIMED Trial: A Case-Cohort Study.
A1 Yu, Edward
A1 Papandreou, Christopher
A1 Ruiz-Canela, Miguel
A1 Guasch-Ferre, Marta
A1 Clish, Clary B
A1 Dennis, Courtney
A1 Liang, Liming
A1 Corella, Dolores
A1 Fitó, Montserrat
A1 Razquin, Cristina
A1 Lapetra, José
A1 Estruch, Ramón
A1 Ros, Emilio
A1 Cofán, Montserrat
A1 Arós, Fernando
A1 Toledo, Estefania
A1 Serra-Majem, Lluis
A1 Sorlí, José V
A1 Hu, Frank B
A1 Martinez-Gonzalez, Miguel A
A1 Salas-Salvado, Jordi
AB Metabolites of the tryptophan-kynurenine pathway (i.e., tryptophan, kynurenine, kynurenic acid, quinolinic acid, 3-hydroxyanthranilic) may be associated with diabetes development. Using a case-cohort design nested in the Prevención con Dieta Mediterránea (PREDIMED) study, we studied the associations of baseline and 1-year changes of these metabolites with incident type 2 diabetes (T2D). Plasma metabolite concentrations were quantified via LC-MS for n = 641 in a randomly selected subcohort and 251 incident cases diagnosed during 3.8 years of median follow-up. Weighted Cox models adjusted for age, sex, body mass index, and other T2D risk factors were used. Baseline tryptophan was associated with higher risk of incident T2D (hazard ratio = 1.29; 95% CI, 1.04-1.61 per SD). Positive changes in quinolinic acid from baseline to 1 year were associated with a higher risk of T2D (hazard ratio = 1.39; 95% CI, 1.09-1.77 per SD). Baseline tryptophan and kynurenic acid were directly associated with changes in homeostatic model assessment for insulin resistance (HOMA-IR) from baseline to 1 year. Concurrent changes in kynurenine, quinolinic acid, 3-hydroxyanthranilic acid, and kynurenine/tryptophan ratio were associated with baseline-to-1-year changes in HOMA-IR. Baseline tryptophan and 1-year increases in quinolinic acid were positively associated with incident T2D. Baseline and 1-year changes in tryptophan metabolites predicted changes in HOMA-IR. Tryptophan levels may initially increase and then deplete as diabetes progresses in severity.
YR 2018
FD 2018-06-08
LK http://hdl.handle.net/10668/12567
UL http://hdl.handle.net/10668/12567
LA en
DS RISalud
RD Apr 7, 2025