TY  - JOUR
AU  - Alvarez-Vergara, Maria I.
AU  - Rosales-Nieves, Alicia E.
AU  - March-Diaz, Rosana
AU  - Rodriguez-Perinan, Guiomar
AU  - Lara-Ureña, Nieves
AU  - Ortega-de San Luis, Clara
AU  - Sanchez-Garcia, Manuel A.
AU  - Martin-Bornez, Miguel
AU  - Gómez-Gálvez, Pedro
AU  - Vicente-Munuera, Pablo
AU  - Fernandez-Gomez, Beatriz
AU  - Marchena, Miguel A.
AU  - Bullones-Bolanos, Andrea S.
AU  - Davila, Jose C.
AU  - Gonzalez-Martinez, Rocio
AU  - Trillo-Contreras, Jose L.
AU  - Sanchez-Hidalgo, Ana C.
AU  - del Toro, Raquel
AU  - Scholl, Francisco G.
AU  - Herrera, Eloisa
AU  - Trepel, Martin
AU  - Körbelin, Jakob
AU  - Escudero, Luis M.
AU  - Villadiego, Javier
AU  - Echevarria, Miriam
AU  - de Castro, Fernando
AU  - Gutierrez, Antonia
AU  - Rabano, Alberto
AU  - Vitorica, Javier
AU  - Pascual, Alberto
PY  - 2021
DO  - 10.1038/s41467-021-23337-z
UR  - http://hdl.handle.net/10668/4516
T2  - Nature Communications
AB  - The human Alzheimer's disease (AD) brain accumulates angiogenic markers but paradoxically, the cerebral microvasculature is reduced around Aß plaques. Here we demonstrate that angiogenesis is started near Aß plaques in both AD mouse models and human...
LA  - en
PB  - Springer Nature
KW  - Alzheimer disease
KW  - Brain
KW  - Endothelial cells
KW  - Presenilins
KW  - Péptidos beta-Amiloides
KW  - Plaque, amyloid
KW  - Blood vessels
KW  - Vascular malformations
KW  - Angiogenesis
KW  - Enfermedad de Alzheimer
KW  - Encéfalo
KW  - Células endoteliales
KW  - Presenilinas
KW  - Péptidos beta-amiloides
KW  - Placa amiloide
KW  - Vasos sanguíneos
KW  - Malformaciones vasculares
KW  - Medical Subject Headings::Diseases::Nervous System Diseases::Neurodegenerative Diseases::Tauopathies::Alzheimer Disease
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Amyloid beta-Peptides
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals
KW  - Medical Subject Headings::Anatomy::Cardiovascular System::Blood Vessels
KW  - Medical Subject Headings::Anatomy::Nervous System::Central Nervous System::Brain
KW  - Medical Subject Headings::Diseases::Animal Diseases::Disease Models, Animal
KW  - Medical Subject Headings::Anatomy::Cells::Epithelial Cells::Endothelial Cells
KW  - Medical Subject Headings::Check Tags::Female
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Gene Expression Profiling
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice::Mice, Inbred Strains::Mice, Inbred C57BL
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice::Mice, Mutant Strains::Mice, Knockout
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice::Mice, Transgenic
KW  - Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Metaplasia::Neovascularization, Pathologic
KW  - Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathological Conditions, Anatomical::Plaque, Amyloid
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Nucleic Acid Amplification Techniques::Polymerase Chain Reaction::Reverse Transcriptase Polymerase Chain Reaction
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Presenilins
KW  - Medical Subject Headings::Anatomy::Cardiovascular System::Blood Vessels::Microvessels
KW  - Medical Subject Headings::Diseases::Skin and Connective Tissue Diseases::Skin Diseases::Skin Abnormalities
TI  - Non-productive angiogenesis disassembles Aß plaque-associated blood vessels
TY  - research article
ER  -