RT Journal Article
T1 Impact of Preexisting Left Bundle Branch Block in Transcatheter Aortic Valve Replacement Recipients.
A1 Fischer, Quentin
A1 Himbert, Dominique
A1 Webb, John G
A1 Eltchaninoff, Helene
A1 Muñoz-García, Antonio J
A1 Tamburino, Corrado
A1 Nombela-Franco, Luis
A1 Nietlispach, Fabian
A1 Moris, Cesar
A1 Ruel, Marc
A1 Dager, Antonio E
A1 Serra, Vicenç
A1 Cheema, Asim N
A1 Amat-Santos, Ignacio J
A1 de Brito, Fabio Sandoli
A1 Ribeiro, Henrique
A1 Abizaid, Alexandre
A1 Sarmento-Leite, Rogério
A1 Dumont, Eric
A1 Barbanti, Marco
A1 Durand, Eric
A1 Alonso Briales, Juan H
A1 Bouleti, Claire
A1 Immè, Sebastiano
A1 Maisano, Francesco
A1 Del Valle, Raquel
A1 Miguel Benitez, Luis
A1 García Del Blanco, Bruno
A1 Côté, Mélanie
A1 Philippon, François
A1 Urena, Marina
A1 Rodés-Cabau, Josep
K1 aortic valve
K1 bundle-branch block
K1 cause of death
K1 echocardiography
K1 follow-up studies
K1 transcatheter aortic valve replacement
AB The impact of preexisting left bundle branch block (LBBB) in transcatheter aortic valve replacement (TAVR) recipients is unknown. The aim of this study was to determine the impact of preexisting LBBB on clinical outcomes after TAVR. This multicenter study evaluated 3404 TAVR candidates according to the presence or absence of LBBB on baseline ECG. TAVR complications and causes of death were defined according to Valve Academic Research Consortium-2 definitions. Follow-up outpatient visits or telephone interviews were conducted at 30 days, 12 months, and yearly thereafter. Echocardiography examinations were performed at baseline, at hospital discharge, and at 1-year follow-up. Preexisting LBBB was present in 398 patients (11.7%) and was associated with an increased risk of permanent pacemaker implantation (PPI; 21.1% versus 14.8%; adjusted odds ratio, 1.51; 95% CI, 1.12-2.04) but not death (7.3% versus 5.5%; adjusted odds ratio, 1.33; 95% CI, 0.84-2.12) at 30 days. At a mean follow-up of 22±21 months, there were no differences between patients with and without preexisting LBBB in overall mortality (adjusted hazard ratio, 0.94; 95% CI, 0.75-1.18) and cardiovascular mortality (adjusted hazard ratio, 0.90; 95% CI, 0.68-1.21). In a subanalysis of 2421 patients without PPI at 30 days and with complete follow-up about the PPI, preexisting LBBB was not associated with an increased risk of PPI or sudden cardiac death. Patients with preexisting LBBB had a lower left ventricular ejection fraction (LVEF) at baseline and at 1-year follow-up ( P  Preexisting LBBB significantly increased the risk of early (but not late) PPI after TAVR, without any significant effect on overall mortality or cardiovascular mortality. Preexisting LBBB was associated with lower LVEF pre-TAVR but did not prevent an increase in LVEF post-TAVR similar to patients without LBBB.
YR 2018
FD 2018
LK http://hdl.handle.net/10668/13339
UL http://hdl.handle.net/10668/13339
LA en
DS RISalud
RD Apr 10, 2025