RT Journal Article
T1 Mixed Th2 and non-Th2 inflammatory pattern in the asthma-COPD overlap: a network approach.
A1 de Llano, Luis Pérez
A1 Cosío, Borja G
A1 Iglesias, Amanda
A1 de Las Cuevas, Natividad
A1 Soler-Cataluña, Juan Jose
A1 Izquierdo, Jose Luis
A1 López-Campos, Jose Luis
A1 Calero, Carmen
A1 Plaza, Vicente
A1 Miravitlles, Marc
A1 Torrego, Alfons
A1 Martinez-Moragon, Eva
A1 Soriano, Joan B
A1 Viña, Antolin Lopez
A1 Bobolea, Irina
K1 COPD mechanisms
K1 IL-13
K1 asthma mechanisms
K1 inflammatory cytokines
K1 network analysis
K1 overlap
AB The asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) is a clinical condition that combines features of those two diseases, and that is difficult to define due to the lack of understanding of the underlying mechanisms. Determining systemic mediators may help clarify the nature of inflammation in patients with ACO. We aimed at investigating the role and interaction of common markers of systemic inflammation (IL-6, IL-8, and tumor necrosis factor-α), Th2-related markers (periostin, IL-5, and IL-13), and IL-17 in asthma, COPD, and ACO. This is a cross-sectional study of patients aged ≥40 years with a post-bronchodilator forced expiratory volume in the first second/forced vital capacity 10 pack-years in a patient with a previous diagnosis of asthma or by the presence of eosinophilia in a patient with a previous diagnosis of COPD. Clinical, functional, and inflammatory parameters were compared between categories using discriminant and network analysis. In total, 109 ACO, 89 COPD, and 94 asthma patients were included. Serum levels (median [interquartile range]) of IL-5 were higher in asthma patients than in COPD patients (2.09 [0.61-3.57] vs 1.11 [0.12-2.42] pg/mL, respectively; p=0.03), and IL-8 levels (median [interquartile range]) were higher in COPD patients than in asthma patients (9.45 [6.61-13.12] vs 7.03 [4.69-10.44] pg/mL, respectively; p Asthma and COPD are two different inflammatory conditions that may overlap in some patients, leading to a mixed inflammatory pattern. IL-13 could be central to the regulation of inflammation in these conditions.
YR 2018
FD 2018-02-12
LK http://hdl.handle.net/10668/12184
UL http://hdl.handle.net/10668/12184
LA en
DS RISalud
RD Apr 8, 2025