RT Journal Article
T1 Impact of obesity-related genes in Spanish population
A1 Martínez-García, Fernando
A1 Mansego, María L.
A1 Rojo-Martínez, Gemma
A1 De Marco-Solar, Griselda
A1 Morcillo, Sonsoles
A1 Soriguer, Federico
A1 Redón, Josep
A1 Pineda Alonso, Monica
A1 Martín-Escudero, Juan C.
A1 Cooper, Richard S.
A1 Chaves, Felipe J.
K1 Obesity
K1 Genetics
K1 FTO gene
K1 Genetic score
K1 España
K1 Obesidad
K1 Genética
K1 Índice de masa corporal
K1 Estudio de asociación del genoma completo
K1 Polimorfismo de nucleótido simple
K1 Andalucía
AB Background: The objective was to investigate the association between BMI and single nucleotide polymorphisms previously identified of obesity-related genes in two Spanish populations. Forty SNPs in 23 obesity-related genes were evaluated in a rural population characterized by a high prevalence of obesity (869 subjects, mean age 46 yr, 62% women, 36% obese) and in an urban population (1425 subjects, mean age 54 yr, 50% women, 19% obese). Genotyping was assessed by using SNPlex and PLINK for the association analysis.Results: Polymorphisms of the FTO were significantly associated with BMI, in the rural population (beta 0.87, p-value <0.001). None of the other SNPs showed significant association after Bonferroni correction in the two populations or in the pooled analysis. A weighted genetic risk score (wGRS) was constructed using the risk allelesof the Tag-SNPs with a positive Beta parameter in both populations. From the first to the fifth quintile of the score, the BMI increased 0.45 kg/m2 in Hortega and 2.0 kg/m2 in Pizarra. Overall, the obesity predictive value was low (less than 1%).Conclusion: The risk associated with polymorphisms is low and the overall effect on BMI or obesity prediction is minimal. A weighted genetic risk score based on genes mainly acting through central nervous system mechanisms was associated with BMI but it yields minimal clinical prediction for the obesity risk in the general population.
PB BioMed Central
YR 2013
FD 2013-11-23
LK http://hdl.handle.net/10668/1502
UL http://hdl.handle.net/10668/1502
LA en
NO Martínez-García F, Mansego ML, Rojo-Martínez G, De Marco-Solar G, Morcillo S, Soriguer F, et al. Impact of obesity-related genes in Spanish population. BMC Genet. 2013; 14:111
NO Journal Article; Research Support, Non-U.S. Gov't;
DS RISalud
RD Mar 14, 2025