RT Journal Article
T1 Association between the APOA2 rs3813627 Single Nucleotide Polymorphism and HDL and APOA1 Levels Through BMI
A1 Boughanem, Hatim
A1 Bandera-Merchán, Borja
A1 Hernández-Alonso, Pablo
A1 Moreno-Morales, Noelia
A1 Tinahones, Francisco José
A1 Lozano, José
A1 Morcillo, Sonsoles
A1 Macias-Gonzalez, Manuel
K1 rs3813627
K1 APOA1
K1 APOA2
K1 HDL
K1 BMI
K1 SNP
K1 Body mass index
K1 Genotype
K1 Single nucleotide polymorphism
K1 High density lipoprotein
K1 Apolipoprotein type 1
K1 Apolipoprotein type 2
K1 Índice de masa corporal
K1 Genotipo
K1 Polimorfismo de nucleótido simple
K1 Lipoproteínas HDL
AB Background: The interaction between obesity and genetic traits on high density lipoprotein (HDL) levels has been extensively studied. The variance of serum HDL has a strong genetic heritability, although the studied variant only explains a small part of this variation. The goal of this study was to investigate the associations between the apolipoprotein type 2 (APOA2) rs3813627 single nucleotide polymorphism (SNP) and anthropometric and biochemical variables, though body mass index (BMI). Methods: This study included 153 subjects (91 overweight/obese (BMI³25 kg/m2) and 62 non-obese individuals (BMI < 25 kg/m2)). The APOA2 rs3813627 SNP was selected and genotyped. Genotype analysis was performed to analyze the associations between APOA2 SNPs and anthropometric and biochemical variables through BMI. Results: The APOA2 rs3813627 TT genotype was associated with low HDL levels in comparison with the APOA2 rs3813627 GG and GT genotype in overweight/obese individuals, but not in the non-obese subjects (p < 0.05). The same trend was observed in the apolipoprotein type 1 (APOA1) protein levels (p < 0.05). Correlation analysis revealed a negative correlation between HDL and APOA1 levels and APOA2 rs3813627 SNP under recessive model (p < 0.05). The odds ratio for low HDL levels was 3.76 and 3.94 for low APOA1 levels. The mediation analysis of APOA2 rs3813627 SNP through BMI showed a full mediation on HDL and partial mediation on APOA1 levels (p < 0.05). Bioinformatic analysis showed that rs3813627 lies in the APOA2 promoter and overlaps motifs for several bound transcription factors. Conclusion: On the basis of these data, the APOA2 rs3813627 SNP is associated with low HDL and APOA1 levels susceptibility, and this effect was mediated by an increased BMI.
PB MDPI
YR 2020
FD 2020-02-27
LK http://hdl.handle.net/10668/4167
UL http://hdl.handle.net/10668/4167
LA en
NO Boughanem H, Bandera-Merchán B, Hernández-Alonso P, Moreno-Morales N, Tinahones FJ, Lozano J, et al. Association between the APOA2 rs3813627 Single Nucleotide Polymorphism and HDL and APOA1 Levels Through BMI. Biomedicines. 2020 Feb 27;8(3):44
DS RISalud
RD Apr 8, 2025