RT Journal Article
T1 Growth rate controls mRNA turnover in steady and non-steady states.
A1 Garcia-Martinez, Jose
A1 Troule, Kevin
A1 Chavez, Sebastian
A1 Perez-Ortin, Jose E
K1 Gene expression
K1 Saccharomyces cerevisiae
K1 growth rate
K1 mRNA stability
K1 transcription
K1 yeast
AB Gene expression has been investigated in relation with growth rate in the yeast Saccharomyces cerevisiae, following different experimental strategies. The expression of some specific gene functional categories increases or decreases with growth rate. Our recently published results have unveiled that these changes in mRNA concentration with growth depend on the relative alteration of mRNA synthesis and decay, and that, in addition to this gene-specific transcriptomic signature of growth, global mRNA turnover increases with growth rate. We discuss here these results in relation with other previous and concurrent publications, and we add new evidence which indicates that growth rate controls mRNA turnover even under non-steady-state conditions.
PB Taylor & Francis Inc.
YR 2016
FD 2016-11-01
LK http://hdl.handle.net/10668/10464
UL http://hdl.handle.net/10668/10464
LA en
NO García-Martínez J, Troulé K, Chávez S, Pérez-Ortín JE. Growth rate controls mRNA turnover in steady and non-steady states. RNA Biol. 2016 Dec;13(12):1175-1181.
DS RISalud
RD Apr 4, 2025